| pubmed-article:11159021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11159021 | lifeskim:mentions | umls-concept:C1516511 | lld:lifeskim |
| pubmed-article:11159021 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:11159021 | lifeskim:mentions | umls-concept:C1518425 | lld:lifeskim |
| pubmed-article:11159021 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:11159021 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11159021 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:11159021 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:11159021 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11159021 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11159021 | pubmed:abstractText | Transcription of the human inducible nitric oxide synthase (iNOS) gene is regulated by inflammatory cytokines in a tissue-specific manner. To determine whether differences in cytokine-induced mRNA levels between pulmonary epithelial cells (A549) and hepatic biliary epithelial cells (AKN-1) result from different protein or DNA regulatory mechanisms, we identified cytokine-induced changes in DNase I-hypersensitive (HS) sites in 13 kb of the iNOS 5'-flanking region. Data showed both constitutive and inducible HS sites in an overlapping yet cell type-specific pattern. Using in vivo footprinting and ligation-mediated PCR to detect potential DNA or protein interactions, we examined one promoter region near -5 kb containing both constitutive and cytokine-induced HS sites. In both cell types, three in vivo footprints were present in both control and cytokine-treated cells, and each mapped within a constitutive HS site. The remaining footprint appeared only in response to cytokine treatment and mapped to an inducible HS site. These studies, performed on chromatin in situ, identify a portion of the molecular mechanisms regulating transcription of the human iNOS gene in both lung- and liver-derived epithelial cells. | lld:pubmed |
| pubmed-article:11159021 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11159021 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11159021 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11159021 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11159021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11159021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11159021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11159021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11159021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11159021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11159021 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11159021 | pubmed:issn | 1040-0605 | lld:pubmed |
| pubmed-article:11159021 | pubmed:author | pubmed-author:WatersM FMF | lld:pubmed |
| pubmed-article:11159021 | pubmed:author | pubmed-author:ChesrownS ESE | lld:pubmed |
| pubmed-article:11159021 | pubmed:author | pubmed-author:BilliarT RTR | lld:pubmed |
| pubmed-article:11159021 | pubmed:author | pubmed-author:NickH SHS | lld:pubmed |
| pubmed-article:11159021 | pubmed:author | pubmed-author:GellerD ADA | lld:pubmed |
| pubmed-article:11159021 | pubmed:author | pubmed-author:MellottJ KJK | lld:pubmed |
| pubmed-article:11159021 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11159021 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:11159021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11159021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11159021 | pubmed:pagination | L390-9 | lld:pubmed |
| pubmed-article:11159021 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:meshHeading | pubmed-meshheading:11159021... | lld:pubmed |
| pubmed-article:11159021 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11159021 | pubmed:articleTitle | Cytokine-induced changes in chromatin structure and in vivo footprints in the inducible NOS promoter. | lld:pubmed |
| pubmed-article:11159021 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, USA. | lld:pubmed |
| pubmed-article:11159021 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11159021 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11159021 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11159021 | lld:pubmed |
