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pubmed-article:11134322pubmed:abstractTextUsing HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrophic virus type 1 Tax peptide-specific CD8(+) T cells ex vivo. Antigen-specific amino acid motifs were identified in the T-cell receptor Vbeta CDR3 region of clonally expanded CD8(+) T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vivo.lld:pubmed
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pubmed-article:11134322pubmed:articleTitleIn vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes.lld:pubmed
pubmed-article:11134322pubmed:affiliationDepartments of Immunology, Imperial College School of Medicine, St. Mary's Campus, London W2 1PG, United Kingdom.lld:pubmed
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