| pubmed-article:11133740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C0036220 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C1447090 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C0524914 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C0065058 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C1332683 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C1705073 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C1332702 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C2610454 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11133740 | lifeskim:mentions | umls-concept:C0162518 | lld:lifeskim |
| pubmed-article:11133740 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11133740 | pubmed:dateCreated | 2001-1-22 | lld:pubmed |
| pubmed-article:11133740 | pubmed:abstractText | The CC chemokine receptor 8 (CCR8) is expressed on monocytes and type 2 T lymphocytes. CCR8 is the sole receptor for the human CC chemokine I-309, as well as for viral monocyte inflammatory protein-I (vMIP-I), a human chemokine homologue induced in human cells by the Kaposi sarcoma-related human herpesvirus-8. Recently it was found that I-309 messenger RNA and protein are expressed by human umbilical vein endothelial cells (HUVECs) and that the secretion of endothelial I-309 is stimulated by apolipoprotein(a). I-309, vMIP-I, and the conditioned medium from apolipoprotein(a)-stimulated HUVECs induce endothelial chemotaxis. A polyclonal anti-CCR8 antibody and a newly developed murine monoclonal antibody against CCR8 inhibited this activity. The G-protein inhibitor pertussis toxin also inhibited endothelial chemotaxis, providing further evidence for a chemokine receptor-mediated effect. Endothelial cells contain CCR8 mRNA as shown by RNA blot analysis as well by direct sequence analysis. Immunohistochemical studies identified CCR8 and I-309 on the endothelium of human atherosclerotic plaques and in endothelial-derived spindle cells of Kaposi sarcoma. These results indicate that CCR8 is an endothelial receptor that may modulate endothelial function. | lld:pubmed |
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| pubmed-article:11133740 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11133740 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11133740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11133740 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11133740 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:11133740 | pubmed:author | pubmed-author:FallonJ TJT | lld:pubmed |
| pubmed-article:11133740 | pubmed:author | pubmed-author:HarpelP CPC | lld:pubmed |
| pubmed-article:11133740 | pubmed:author | pubmed-author:TaubmanM BMB | lld:pubmed |
| pubmed-article:11133740 | pubmed:author | pubmed-author:HaqueN SNS | lld:pubmed |
| pubmed-article:11133740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11133740 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11133740 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:11133740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11133740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11133740 | pubmed:pagination | 39-45 | lld:pubmed |
| pubmed-article:11133740 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11133740 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11133740 | pubmed:articleTitle | The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium. | lld:pubmed |
| pubmed-article:11133740 | pubmed:affiliation | Department of Medicine, Divisions of Hematology and Cardiology, and the Department of Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA. | lld:pubmed |
| pubmed-article:11133740 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11133740 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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