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rdf:type |
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lifeskim:mentions |
umls-concept:C0036220,
umls-concept:C0065058,
umls-concept:C0086418,
umls-concept:C0086597,
umls-concept:C0162518,
umls-concept:C0205263,
umls-concept:C0225336,
umls-concept:C0524914,
umls-concept:C1332683,
umls-concept:C1332702,
umls-concept:C1447090,
umls-concept:C1705073,
umls-concept:C1948023,
umls-concept:C2610454
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-22
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pubmed:abstractText |
The CC chemokine receptor 8 (CCR8) is expressed on monocytes and type 2 T lymphocytes. CCR8 is the sole receptor for the human CC chemokine I-309, as well as for viral monocyte inflammatory protein-I (vMIP-I), a human chemokine homologue induced in human cells by the Kaposi sarcoma-related human herpesvirus-8. Recently it was found that I-309 messenger RNA and protein are expressed by human umbilical vein endothelial cells (HUVECs) and that the secretion of endothelial I-309 is stimulated by apolipoprotein(a). I-309, vMIP-I, and the conditioned medium from apolipoprotein(a)-stimulated HUVECs induce endothelial chemotaxis. A polyclonal anti-CCR8 antibody and a newly developed murine monoclonal antibody against CCR8 inhibited this activity. The G-protein inhibitor pertussis toxin also inhibited endothelial chemotaxis, providing further evidence for a chemokine receptor-mediated effect. Endothelial cells contain CCR8 mRNA as shown by RNA blot analysis as well by direct sequence analysis. Immunohistochemical studies identified CCR8 and I-309 on the endothelium of human atherosclerotic plaques and in endothelial-derived spindle cells of Kaposi sarcoma. These results indicate that CCR8 is an endothelial receptor that may modulate endothelial function.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/CCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoprotein(a),
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR8,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella,
http://linkedlifedata.com/resource/pubmed/chemical/vMIP-1 protein, Human herpesvirus 8
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-45
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11133740-Antibodies,
pubmed-meshheading:11133740-Chemokine CCL1,
pubmed-meshheading:11133740-Chemokine CXCL12,
pubmed-meshheading:11133740-Chemokines, CC,
pubmed-meshheading:11133740-Chemokines, CXC,
pubmed-meshheading:11133740-Chemotactic Factors,
pubmed-meshheading:11133740-Chemotaxis,
pubmed-meshheading:11133740-Coronary Artery Disease,
pubmed-meshheading:11133740-Culture Media, Conditioned,
pubmed-meshheading:11133740-Endothelium, Vascular,
pubmed-meshheading:11133740-Herpesvirus 8, Human,
pubmed-meshheading:11133740-Humans,
pubmed-meshheading:11133740-Immunohistochemistry,
pubmed-meshheading:11133740-Lipoprotein(a),
pubmed-meshheading:11133740-Macrophage Inflammatory Proteins,
pubmed-meshheading:11133740-Pertussis Toxin,
pubmed-meshheading:11133740-RNA, Messenger,
pubmed-meshheading:11133740-Receptors, CCR8,
pubmed-meshheading:11133740-Receptors, Chemokine,
pubmed-meshheading:11133740-Sarcoma, Kaposi,
pubmed-meshheading:11133740-Umbilical Veins,
pubmed-meshheading:11133740-Viral Proteins,
pubmed-meshheading:11133740-Virulence Factors, Bordetella
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pubmed:year |
2001
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pubmed:articleTitle |
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium.
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pubmed:affiliation |
Department of Medicine, Divisions of Hematology and Cardiology, and the Department of Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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