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pubmed-article:11125216pubmed:abstractTextCells respond to osmotic swelling by releasing inorganic ions and small organic molecules (organic osmolytes). In many cell-types, osmotic swelling results in the activation of an outwardly-rectifying anion-selective current. The channel underlying this current has a significant permeability to a number of organic osmolytes and may play a role in the hypoosmotically-activated efflux of these compounds. However, there is also evidence that the volume-regulatory efflux of organic osmolytes involves other pathways which may be selective for neutral osmolytes over anions.lld:pubmed
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pubmed-article:11125216pubmed:authorpubmed-author:JunankarP RPRlld:pubmed
pubmed-article:11125216pubmed:authorpubmed-author:KirkKKlld:pubmed
pubmed-article:11125216pubmed:copyrightInfoCopyright 2000 S. Karger AG, Basel.lld:pubmed
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pubmed-article:11125216pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11125216pubmed:articleTitleOrganic osmolyte channels: a comparative view.lld:pubmed
pubmed-article:11125216pubmed:affiliationDivision of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, Australia.lld:pubmed
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