Linked Life Data

11123330

Source:http://linkedlifedata.com/resource/pubmed/id/11123330

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-1-3
pubmed:abstractText
Despite high viral loads, T cells from sooty mangabey (SM) monkeys that are naturally infected with SIV but remain clinically asymptomatic, proliferate and demonstrate normal Ag-specific memory recall CD4(+) T cell responses. In contrast, CD4(+) T cells from rhesus macaques (RM) experimentally infected with SIV lose Ag-specific memory recall responses and develop immunological anergy. To elucidate the mechanisms for these distinct outcomes of lentiviral infection, highly enriched alloreactive CD4(+) T cells from humans, RM, and SM were anergized by TCR-only stimulation (signal 1 alone) and subsequently challenged with anti-CD3/anti-CD28 Abs (signals 1 + 2). Whereas alloreactive CD4(+)T cells from humans and RM became anergized, surprisingly, CD4(+) T cells from SM showed marked proliferation and IL-2 synthesis after restimulation. This resistance to undergo anergy was not secondary to a global deficiency in anergy induction of CD4(+) T cells from SM since incubation of CD4(+) T cells with anti-CD3 alone in the presence of rapamycin readily induced anergy in these cells. The resistance to undergo anergy was reasoned to be due to the ability of CD4(+) T cells from SM to synthesize IL-2 when incubated with anti-CD3 alone. Analysis of phosphorylated kinases involved in T cell activation showed that the activation of CD4(+) T cells by signal 1 in SM elicited a pattern of response that required both signals 1 + 2 in humans and RM. This function of CD4(+) T cells from SM may contribute to the resistance of this species to SIV-induced disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
166
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
506-16
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11123330-Adult, pubmed-meshheading:11123330-Animals, pubmed-meshheading:11123330-Base Sequence, pubmed-meshheading:11123330-CD4-Positive T-Lymphocytes, pubmed-meshheading:11123330-Cells, Cultured, pubmed-meshheading:11123330-Cercocebus atys, pubmed-meshheading:11123330-Clonal Anergy, pubmed-meshheading:11123330-Cyclosporine, pubmed-meshheading:11123330-Cytokines, pubmed-meshheading:11123330-Epitopes, T-Lymphocyte, pubmed-meshheading:11123330-Humans, pubmed-meshheading:11123330-Hydroxyurea, pubmed-meshheading:11123330-Immunity, Innate, pubmed-meshheading:11123330-Kinetics, pubmed-meshheading:11123330-Lymphocyte Activation, pubmed-meshheading:11123330-MAP Kinase Signaling System, pubmed-meshheading:11123330-Macaca mulatta, pubmed-meshheading:11123330-Mitogen-Activated Protein Kinases, pubmed-meshheading:11123330-Molecular Sequence Data, pubmed-meshheading:11123330-Muromonab-CD3, pubmed-meshheading:11123330-Simian Acquired Immunodeficiency Syndrome, pubmed-meshheading:11123330-Sirolimus
pubmed:year
2001
pubmed:articleTitle
Relative resistance in the development of T cell anergy in CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. pbostik@emory.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.