Linked Life Data

11122354

Source:http://linkedlifedata.com/resource/pubmed/id/11122354

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-2-9
pubmed:abstractText
Cytokines act on the brain to induce fever and behavioural depression after infection. Although several mechanisms of cytokine-to-brain communication have been proposed, their physiological significance is unclear. We propose that behavioural depression is mediated by the vagus nerve activating limbic structures, while fever would primarily be due to humoral mechanisms affecting the preoptic area, including interleukin-6 (IL-6) action on the organum vasculosum of the laminae terminalis (OVLT) and induction of prostaglandins. This study assessed the effects of subdiaphragmatic vagotomy in rats on fever, behavioural depression, as measured by the social interaction test, and Fos expression in the brain. These responses were compared with induction of the prostaglandin-producing enzyme cyclooxygenase-2 and the transcription factor Stat3 that translocates after binding of IL-6. Vagotomy blocked behavioural depression after intraperitoneal injection of recombinant rat IL-1beta (25 microg/kg) or lipopolysaccharide (250 microg/kg; LPS) and prevented Fos expression in limbic structures and ventromedial preoptic area, but not in the OVLT. Fever was not affected by vagotomy, but associated with translocation of Stat3 in the OVLT and cyclooxygenase-2 induction around blood vessels. These results indicate that the recently proposed vagal link between the immune system and the brain activates limbic structures to induce behavioural depression after abdominal inflammation. Although the vagus might play a role in fever in response to low doses of LPS by activating the ventromedial preoptic area, it is likely to be overridden during more severe infection by action of circulating IL-6 on the OVLT or prostaglandins induced along blood vessels of the preoptic area.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4434-46
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11122354-Animals, pubmed-meshheading:11122354-Body Temperature, pubmed-meshheading:11122354-Brain, pubmed-meshheading:11122354-Cyclooxygenase 2, pubmed-meshheading:11122354-Escherichia coli, pubmed-meshheading:11122354-Fever, pubmed-meshheading:11122354-Gene Expression Regulation, pubmed-meshheading:11122354-Genes, fos, pubmed-meshheading:11122354-Interleukin-1, pubmed-meshheading:11122354-Interleukin-6, pubmed-meshheading:11122354-Isoenzymes, pubmed-meshheading:11122354-Limbic System, pubmed-meshheading:11122354-Lipopolysaccharides, pubmed-meshheading:11122354-Male, pubmed-meshheading:11122354-Preoptic Area, pubmed-meshheading:11122354-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:11122354-Rats, pubmed-meshheading:11122354-Rats, Wistar, pubmed-meshheading:11122354-Recombinant Proteins, pubmed-meshheading:11122354-Social Behavior, pubmed-meshheading:11122354-Vagotomy, pubmed-meshheading:11122354-Vagus Nerve
pubmed:year
2000
pubmed:articleTitle
The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis.
pubmed:affiliation
INSERM U394, Neurobiologie Intégrative, Institut François Magendie, Rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France. jpkonsman@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't