| pubmed-article:11122135 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C1527169 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C0079459 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C0210630 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C0040739 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C0585361 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:11122135 | lifeskim:mentions | umls-concept:C0524864 | lld:lifeskim |
| pubmed-article:11122135 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11122135 | pubmed:dateCreated | 2001-1-26 | lld:pubmed |
| pubmed-article:11122135 | pubmed:abstractText | To evaluate the schedule dependency of granulocyte colony-stimulating factor (G-CSF) (filgrastim) for stem cell mobilization, we conducted a randomized comparison in 50 healthy donors, with one subcutaneous daily injection of 10 microg/kg G-CSF (n = 25) compared with twice injections daily of 5 microg/kg G-CSF (n = 25). The two groups were well balanced for age, body weight and sex. G-CSF application was performed on an out-patient basis and leukapheresis was started in all donors on day 5. The most frequent side-effects of G-CSF were mild to moderate bone pain (88%), mild headache (72%), mild fatigue (48-60%) and nausea (8%) without differences between the two groups. The CD34(+) cell count in the first apheresis was 5.4 x 10(6)/kg donor weight (range 2.8-13.3) in the 2 x 5 microg/kg group compared with 4.0 x 10(6)/kg (range 0.4-8.8) in the 1 x 10 microg/kg group (P = 0.007). The target of collecting > 3.0 x 10(6) CD34(+) cells/kg donor weight with one apheresis procedure was achieved in 24/25 (96%) donors in the 2 x 5 microg/kg group and in 17/25 (68%) donors in the 1 x 10 microg/kg group. The target of collecting > 5.0 x 10(6) CD34(+) cells/kg in the first apheresis was achieved in 64% in the 2 x 5 microg/kg group, but in only 36% in the 1 x 10 microg/kg group. The progenitor cell assay for granulocyte-macrophage colony-forming units (CFU-GM) and erythroid burst-forming units (BFU-E) was higher in the 2 x 5 microg/kg group than in the 1 x 10 microg/kg group (7.0 vs. 3.5 x 10(5)/kg, P = 0.01; 6.6 vs. 5.0 x 10(5)/kg; P = 0.1). Administering G-CSF (filgrastim) at a dosage of 5 microg/kg twice daily rather than 10 microg/kg once daily is recommended; this leads to a higher CD34(+) cell yield and requires fewer apheresis procedures without increasing toxicity or cost. | lld:pubmed |
| pubmed-article:11122135 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11122135 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11122135 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11122135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11122135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11122135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11122135 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11122135 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11122135 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11122135 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:11122135 | pubmed:author | pubmed-author:KrügerWW | lld:pubmed |
| pubmed-article:11122135 | pubmed:author | pubmed-author:ZanderA RAR | lld:pubmed |
| pubmed-article:11122135 | pubmed:author | pubmed-author:GutensohnKK | lld:pubmed |
| pubmed-article:11122135 | pubmed:author | pubmed-author:LöligerCC | lld:pubmed |
| pubmed-article:11122135 | pubmed:author | pubmed-author:KrögerNN | lld:pubmed |
| pubmed-article:11122135 | pubmed:author | pubmed-author:CortesLL | lld:pubmed |
| pubmed-article:11122135 | pubmed:author | pubmed-author:CarreroII | lld:pubmed |
| pubmed-article:11122135 | pubmed:author | pubmed-author:RengeiBB | lld:pubmed |
| pubmed-article:11122135 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11122135 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:11122135 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11122135 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11122135 | pubmed:pagination | 761-5 | lld:pubmed |
| pubmed-article:11122135 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:11122135 | pubmed:meshHeading | pubmed-meshheading:11122135... | lld:pubmed |
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| pubmed-article:11122135 | pubmed:meshHeading | pubmed-meshheading:11122135... | lld:pubmed |
| pubmed-article:11122135 | pubmed:meshHeading | pubmed-meshheading:11122135... | lld:pubmed |
| pubmed-article:11122135 | pubmed:meshHeading | pubmed-meshheading:11122135... | lld:pubmed |
| pubmed-article:11122135 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11122135 | pubmed:articleTitle | A randomized comparison of once versus twice daily recombinant human granulocyte colony-stimulating factor (filgrastim) for stem cell mobilization in healthy donors for allogeneic transplantation. | lld:pubmed |
| pubmed-article:11122135 | pubmed:affiliation | Department of Bone Marrow Transplantation, University of Hamburg, Germany. nkroeger@uke.uni-hamburg.de | lld:pubmed |
| pubmed-article:11122135 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11122135 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11122135 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11122135 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11122135 | lld:pubmed |
