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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1975-5-9
|
| pubmed:abstractText |
The study was performed on adult mongrel cats to investigate synaptic structures of nerve terminals in the dorso-medial portion of the nucleus tractus solitarius (NTS), where majorities of the cardiovascular afferent fibers terminate and a dense plexus of the catecholaminergic nerves exists. In normal control groups, axo-dendritic and axo-somatic contacts were commonly observed but no axo-axonic contacts were seen. Synaptic vesicles were almost exclusively spherical (97%) and less frequently flat (3%). Small cored vesicles were not observed in animals with formalin-glutaraldehyde and osmium tetroxide fixation. Two or three days after denervation of IXth and Xth cranial nerves, degenerated axon varicosities occupied about 15-20% of total population. Quantitative analysis after intracisternal injection of 5-hydroxydopamine revealed 3 different types of the varicosity: varicosities with spherical clear vesicles (85%), flat clear vesicles (3%) and small cored vesicles (12%). Axon varicosities with small cored vesicles predominantly exhibited axo-dendritic synapses and occasionally showed the closed apposition with those containing spherical clear vesicles. 6-Hydroxydopamine produced a minimal degree of degenerative changes in some axon varicosities (less than 5%). Treatment with 5-hydroxydopamine after IXth and Xth cranial nerve section gave intact axon varicosities with small cored vesicles. In conclusion, there is a relatively dense innervation of catecholaminergic nerves in the dorso-medial portion of the NTS, which apparently does not stem from the IXth and Xth cranial nerves. Possible roles of catecholaminergic nerves are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0006-8993
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
31-46
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1111825-Animals,
pubmed-meshheading:1111825-Axons,
pubmed-meshheading:1111825-Cardiovascular System,
pubmed-meshheading:1111825-Cats,
pubmed-meshheading:1111825-Cranial Nerves,
pubmed-meshheading:1111825-Denervation,
pubmed-meshheading:1111825-Female,
pubmed-meshheading:1111825-Hydroxydopamines,
pubmed-meshheading:1111825-Male,
pubmed-meshheading:1111825-Medulla Oblongata,
pubmed-meshheading:1111825-Microscopy, Electron,
pubmed-meshheading:1111825-Microscopy, Fluorescence,
pubmed-meshheading:1111825-Nerve Endings,
pubmed-meshheading:1111825-Neural Pathways,
pubmed-meshheading:1111825-Neurons, Afferent,
pubmed-meshheading:1111825-Reflex,
pubmed-meshheading:1111825-Synapses,
pubmed-meshheading:1111825-Synaptic Vesicles
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
The synaptic structure of catecholaminergic axon varicosities in the dorso-medial portion of the nucleus tractus solitarius of the cat: possible roles in the regulation of cardiovascular reflexes.
|
| pubmed:publicationType |
Journal Article
|