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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
2001-1-16
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pubmed:databankReference |
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pubmed:abstractText |
The intracellular protease from Pyrococcus horikoshii (PH1704) and PfpI from Pyrococcus furiosus are members of a class of intracellular proteases that have no sequence homology to any other known protease family. We report the crystal structure of PH1704 at 2.0-A resolution. The protease is tentatively identified as a cysteine protease based on the presence of cysteine (residue 100) in a nucleophile elbow motif. In the crystal, PH1704 forms a hexameric ring structure, and the active sites are formed at the interfaces between three pairs of monomers.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-10022351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-10089316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-10631785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-1279805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-1409539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-16348684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-2117873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-2184035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-2199796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-2395881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-2443441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-3263420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-6667333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-7638617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-7725097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-8377180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-8548458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-8626329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-9033594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-9087403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-9254694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-9390550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-9390554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-9714877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-9721091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11114201-9757107
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14079-84
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pubmed:dateRevised |
2010-9-14
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pubmed:meshHeading |
pubmed-meshheading:11114201-Amino Acid Sequence,
pubmed-meshheading:11114201-Archaeal Proteins,
pubmed-meshheading:11114201-Crystallography, X-Ray,
pubmed-meshheading:11114201-Endopeptidases,
pubmed-meshheading:11114201-Intracellular Fluid,
pubmed-meshheading:11114201-Models, Molecular,
pubmed-meshheading:11114201-Molecular Sequence Data,
pubmed-meshheading:11114201-Peptide Hydrolases,
pubmed-meshheading:11114201-Protein Structure, Quaternary,
pubmed-meshheading:11114201-Pyrococcus,
pubmed-meshheading:11114201-Recombinant Fusion Proteins,
pubmed-meshheading:11114201-Sequence Homology, Amino Acid
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pubmed:year |
2000
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pubmed:articleTitle |
Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution.
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pubmed:affiliation |
Department of Chemistry, University of California, Berkeley, CA 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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