Source:http://linkedlifedata.com/resource/pubmed/id/11109196
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2001-2-2
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pubmed:abstractText |
High-dose cyclophosphamide is the nucleus for virtually all high-dose chemotherapy protocols. Non-hematologic dose-limiting toxicity is represented by acute cardiomyopathy, even fatal in a minority of patients. The pathophysiology of such a cardiotoxicity is still poorly understood. Postmortem studies revealed hemorrhagic myocardial cell death, endothelial damage, and interstitial edema. Recently troponins, in particular troponin I, have been found to represent uniquely sensitive and specific markers of myocyte membrane integrity, thus to increase in response to myocardial cell damage in different clinical settings.
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pubmed:language |
ita
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1129-4728
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1457-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11109196-Adult,
pubmed-meshheading:11109196-Antineoplastic Agents, Alkylating,
pubmed-meshheading:11109196-Breast Neoplasms,
pubmed-meshheading:11109196-Cyclophosphamide,
pubmed-meshheading:11109196-Electrocardiography,
pubmed-meshheading:11109196-Female,
pubmed-meshheading:11109196-Heart Diseases,
pubmed-meshheading:11109196-Humans,
pubmed-meshheading:11109196-Middle Aged,
pubmed-meshheading:11109196-Troponin I
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pubmed:year |
2000
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pubmed:articleTitle |
[Assessment of cardiotoxicity of high dose cyclophosphamide with electrocardiographic, echocardiographic, and troponin I monitoring in patients with breast tumors].
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pubmed:affiliation |
Divisione di Cardiologia, Ospedale Civile San Bortolo, Vicenza. benvenuto1@libero.it
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pubmed:publicationType |
Journal Article,
English Abstract
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