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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-1-7
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pubmed:abstractText |
We report here that the apoptosis-promoting protein TIA-1 regulates alternative pre-mRNA splicing of the Drosophila melanogaster gene male-specific-lethal 2 and of the human apoptotic gene Fas. TIA-1 associates selectively with pre-mRNAs that contain 5' splice sites followed by U-rich sequences. TIA-1 binding to the U-rich stretches facilitates 5' splice site recognition by U1 snRNP. This activity is critical for activation of the weak 5' splice site of msl-2 and for modulating the choice of splice site partner in Fas. Structural and functional similarities with the Saccharomyces cerevisiae splicing factor Nam8 suggest striking evolutionary conservation of a mechanism of pre-mRNA splicing regulation that controls biological processes as diverse as meiosis in yeast, dosage compensation in fruit flies, or programmed cell death in humans.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NAM8 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(A)-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Splice Sites,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonuclease H,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoprotein, U1 Small Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins, Small Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TIA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/msl-2 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/splicing factor U2AF
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1089-98
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11106748-Alternative Splicing,
pubmed-meshheading:11106748-Animals,
pubmed-meshheading:11106748-Antigens, CD95,
pubmed-meshheading:11106748-Apoptosis,
pubmed-meshheading:11106748-Base Sequence,
pubmed-meshheading:11106748-Binding Sites,
pubmed-meshheading:11106748-Conserved Sequence,
pubmed-meshheading:11106748-DNA-Binding Proteins,
pubmed-meshheading:11106748-Drosophila Proteins,
pubmed-meshheading:11106748-Drosophila melanogaster,
pubmed-meshheading:11106748-Fibroblasts,
pubmed-meshheading:11106748-Fungal Proteins,
pubmed-meshheading:11106748-HeLa Cells,
pubmed-meshheading:11106748-Humans,
pubmed-meshheading:11106748-Introns,
pubmed-meshheading:11106748-Membrane Proteins,
pubmed-meshheading:11106748-Nuclear Proteins,
pubmed-meshheading:11106748-Poly(A)-Binding Proteins,
pubmed-meshheading:11106748-Protein Binding,
pubmed-meshheading:11106748-Proteins,
pubmed-meshheading:11106748-RNA, Messenger,
pubmed-meshheading:11106748-RNA Precursors,
pubmed-meshheading:11106748-RNA Splice Sites,
pubmed-meshheading:11106748-RNA-Binding Proteins,
pubmed-meshheading:11106748-Ribonuclease H,
pubmed-meshheading:11106748-Ribonucleoprotein, U1 Small Nuclear,
pubmed-meshheading:11106748-Ribonucleoproteins,
pubmed-meshheading:11106748-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:11106748-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:11106748-Substrate Specificity,
pubmed-meshheading:11106748-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing.
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pubmed:affiliation |
Gene Expression Programme European Molecular Biology Laboratory Meyerhofstrasse 1 D-69117, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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