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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-3-8
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pubmed:abstractText |
The topoisomerase II-targeted drugs, epipodophyllotoxins and anthracyclines, have been shown to induce therapy-related AML (t-AML) characterized by a short latency period after chemotherapy, the absence of prior myelodysplastic syndrome and stereotyped chromosome aberrations. Few reports have been published on patients treated with the anthracenedione mitoxantrone which also targets topoisomerase II. We observed 10 cases of such t-AML over a 7-year-period in breast cancer patients treated with mitoxantrone combined with fluorouracil, cyclophosphamide and regional radiotherapy, and in three cases with vindesine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0923-7534
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pubmed:author |
pubmed-author:BarilMM,
pubmed-author:BenboubkerLL,
pubmed-author:BinetCC,
pubmed-author:BrémondJ LJL,
pubmed-author:CalaisGG,
pubmed-author:CartronGG,
pubmed-author:ColombatPP,
pubmed-author:DelainMM,
pubmed-author:GeorgetM TMT,
pubmed-author:LamagnèreJ PJP,
pubmed-author:LeloupRR,
pubmed-author:LetortorecSS,
pubmed-author:LinassierCC,
pubmed-author:PetitAA,
pubmed-author:RabanNN
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1289-94
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11106118-Adult,
pubmed-meshheading:11106118-Aged,
pubmed-meshheading:11106118-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11106118-Breast Neoplasms,
pubmed-meshheading:11106118-Combined Modality Therapy,
pubmed-meshheading:11106118-Cyclophosphamide,
pubmed-meshheading:11106118-Female,
pubmed-meshheading:11106118-Fluorouracil,
pubmed-meshheading:11106118-Humans,
pubmed-meshheading:11106118-Leukemia, Myeloid, Acute,
pubmed-meshheading:11106118-Middle Aged,
pubmed-meshheading:11106118-Mitoxantrone,
pubmed-meshheading:11106118-Neoplasms, Second Primary
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pubmed:year |
2000
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pubmed:articleTitle |
Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy.
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pubmed:affiliation |
C. H. R. U. Bretonneau, Tours, France. linassier2med.univ-tours.fr.
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pubmed:publicationType |
Journal Article
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