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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-3-8
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pubmed:abstractText |
It has been suggested that a diminished folate status may enhance colorectal carcinogenesis by causing DNA hypomethylation. The aims of the present study were to assess the impact of different levels of folate depletion on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and DNA hypomethylation in the colon of male Sprague-Dawley rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0815-9319
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1158-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11106096-Animals,
pubmed-meshheading:11106096-Azoxymethane,
pubmed-meshheading:11106096-Carcinogens,
pubmed-meshheading:11106096-Chromatography, High Pressure Liquid,
pubmed-meshheading:11106096-Colon,
pubmed-meshheading:11106096-Colonic Neoplasms,
pubmed-meshheading:11106096-DNA Methylation,
pubmed-meshheading:11106096-Data Interpretation, Statistical,
pubmed-meshheading:11106096-Disease Models, Animal,
pubmed-meshheading:11106096-Folic Acid,
pubmed-meshheading:11106096-Folic Acid Deficiency,
pubmed-meshheading:11106096-Homocysteine,
pubmed-meshheading:11106096-Injections, Subcutaneous,
pubmed-meshheading:11106096-Intestinal Mucosa,
pubmed-meshheading:11106096-Liver,
pubmed-meshheading:11106096-Male,
pubmed-meshheading:11106096-Precancerous Conditions,
pubmed-meshheading:11106096-Rats,
pubmed-meshheading:11106096-Rats, Sprague-Dawley,
pubmed-meshheading:11106096-Risk Factors,
pubmed-meshheading:11106096-Time Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status.
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pubmed:affiliation |
University of Adelaide, Department of Medicine, tCSIRO, Health Sciences and Nutrition, South Australia, Australia. richard.leleu@dhn.csiro.au
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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