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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional cues that act as an attractant for some cell types and as a repellent for others. Several lines of evidence suggest that two classes of receptors, the deleted in colorectal cancer (DCC) family and the UNC-5 family, mediate the attractant and repellent response to netrin. Although netrins were first identified as diffusible long-range cues for developing axons, recent findings provide evidence that they also function as short-range cues close to the surface of the cells that produce them. This short-range function of netrin contributes to guiding neurite outgrowth and mediating cell-cell interactions during development and perhaps also in adults.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fetal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NTN4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ntn4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/UNC-5 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/netrin receptors,
http://linkedlifedata.com/resource/pubmed/chemical/netrin-1,
http://linkedlifedata.com/resource/pubmed/chemical/netrin-2,
http://linkedlifedata.com/resource/pubmed/chemical/netrin-3
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pubmed:status |
MEDLINE
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pubmed:issn |
0829-8211
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
569-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11103947-Animals,
pubmed-meshheading:11103947-Axons,
pubmed-meshheading:11103947-Caenorhabditis elegans,
pubmed-meshheading:11103947-Caenorhabditis elegans Proteins,
pubmed-meshheading:11103947-Cell Movement,
pubmed-meshheading:11103947-Diffusion,
pubmed-meshheading:11103947-Dose-Response Relationship, Drug,
pubmed-meshheading:11103947-Drosophila melanogaster,
pubmed-meshheading:11103947-Evolution, Molecular,
pubmed-meshheading:11103947-Eye Proteins,
pubmed-meshheading:11103947-Fetal Proteins,
pubmed-meshheading:11103947-Genes, DCC,
pubmed-meshheading:11103947-Helminth Proteins,
pubmed-meshheading:11103947-Humans,
pubmed-meshheading:11103947-Insect Proteins,
pubmed-meshheading:11103947-Membrane Proteins,
pubmed-meshheading:11103947-Mice,
pubmed-meshheading:11103947-Mice, Knockout,
pubmed-meshheading:11103947-Models, Neurological,
pubmed-meshheading:11103947-Multigene Family,
pubmed-meshheading:11103947-Muscle Proteins,
pubmed-meshheading:11103947-Nerve Growth Factors,
pubmed-meshheading:11103947-Nerve Tissue Proteins,
pubmed-meshheading:11103947-Neuromuscular Junction,
pubmed-meshheading:11103947-Receptors, Cell Surface,
pubmed-meshheading:11103947-Receptors, Growth Factor,
pubmed-meshheading:11103947-Retinal Ganglion Cells,
pubmed-meshheading:11103947-Species Specificity,
pubmed-meshheading:11103947-Stimulation, Chemical,
pubmed-meshheading:11103947-Tumor Suppressor Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Cellular mechanisms of netrin function: long-range and short-range actions.
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pubmed:affiliation |
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, QC, Canada. mddy@musica.mcgill.ca
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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