Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-12-28
pubmed:abstractText
Although host radiation allows a parasite to expand its ecological niche, traits governing the infection of multiple host types can decrease fitness in the original or alternate host environments. Reasons for this reduction in fitness include slower replication due to added genetic material or modifications, fitness trade-offs across host environments, and weaker selection resulting from simultaneous adaptation to multiple habitats. We examined the consequences of host radiation using vesicular stomatitis virus (VSV) and mammalian host cells in tissue culture. Replicate populations of VSV were allowed to evolve for 100 generations on the original host (BHK cells), on either of two novel hosts (HeLa and MDCK cells), or in environments where the availability of novel hosts fluctuated in a predictable or random way. As expected, each experimental population showed a substantial fitness gain in its own environment, but those evolved on new hosts (constant or fluctuating) suffered reduced competitiveness on the original host. However, whereas evolution on one novel host negatively correlated with performance on the unselected novel host, adaptation in fluctuating environments led to fitness improvements in both novel habitats.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-10092452, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-10196330, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-10481012, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-10628966, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-10729131, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-10860958, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-18811369, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-2033662, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-2417417, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-6204381, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-7474092, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-7597039, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-8380072, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-9454708, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-9665128, http://linkedlifedata.com/resource/pubmed/commentcorrection/11102349-9822369
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1465-70
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Cost of host radiation in an RNA virus.
pubmed:affiliation
Institut Cavanilles de Biodiversitat i Biología Evolutiva and Departament de Genètica, Universitat de València, 46071 València, Spain.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't