| pubmed-article:11100147 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C0872341 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:11100147 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:11100147 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11100147 | pubmed:dateCreated | 2000-12-8 | lld:pubmed |
| pubmed-article:11100147 | pubmed:abstractText | Cerebellar long-term depression (LTD) is a calcium-dependent process in which coincident activity of parallel fiber (PF) and climbing fiber (CF) synapses causes a long-lasting decrease in PF synaptic strength onto Purkinje cells. Here we show that pairing CF activation with bursts of PF activity triggers large (>10 microM) calcium signals in Purkinje cell dendrites. When PFs are densely activated, signals span whole dendritic branchlets and are mediated by voltage-dependent calcium entry. When PFs are sparsely activated, however, signals are restricted to single spines and blocked by metabotropic glutamate receptor antagonists. Single-spine signals and sparse-stimulation LTD are also blocked by thapsigargin, indicating that calcium must be released from stores. Single-spine signals and sparse-stimulation LTD are greatest when PF activation precedes the CF activation within 50-200 ms. This timing rule matches the properties of several forms of motor learning, providing a link between behavior and functional properties of cerebellar synaptic plasticity. | lld:pubmed |
| pubmed-article:11100147 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11100147 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11100147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11100147 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11100147 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11100147 | pubmed:issn | 1097-6256 | lld:pubmed |
| pubmed-article:11100147 | pubmed:author | pubmed-author:WangS SSS | lld:pubmed |
| pubmed-article:11100147 | pubmed:author | pubmed-author:DenkWW | lld:pubmed |
| pubmed-article:11100147 | pubmed:author | pubmed-author:HäusserMM | lld:pubmed |
| pubmed-article:11100147 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11100147 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:11100147 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11100147 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11100147 | pubmed:pagination | 1266-73 | lld:pubmed |
| pubmed-article:11100147 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11100147 | pubmed:meshHeading | pubmed-meshheading:11100147... | lld:pubmed |
| pubmed-article:11100147 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11100147 | pubmed:articleTitle | Coincidence detection in single dendritic spines mediated by calcium release. | lld:pubmed |
| pubmed-article:11100147 | pubmed:affiliation | Biological Computation Research Department, Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974, USA. | lld:pubmed |
| pubmed-article:11100147 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11100147 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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