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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2000-12-1
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pubmed:abstractText |
The Kv4.3-encoded current (I:(Kv4.3)) has been identified as the major component of the voltage-dependent Ca(2+)-independent transient outward current (I:(to1)) in human and canine ventricular cells. Experimental evidence supports a correlation between I:(to1) density and prominence of the phase 1 notch; however, the role of I:(to1) in modulating action potential duration (APD) remains unclear. To help resolve this role, Markov state models of the human and canine Kv4.3- and Kv1.4-encoded currents at 35 degrees C are developed on the basis of experimental measurements. A model of canine I:(to1) is formulated as the combination of these Kv4.3 and Kv1.4 currents and is incorporated into an existing canine ventricular myocyte model. Simulations demonstrate strong coupling between L-type Ca(2+) current and I:(Kv4.3) and predict a bimodal relationship between I:(Kv4.3) density and APD whereby perturbations in I:(Kv4.3) density may produce either prolongation or shortening of APD, depending on baseline I:(to1) current level.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1026-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11090548-Action Potentials,
pubmed-meshheading:11090548-Animals,
pubmed-meshheading:11090548-Calcium,
pubmed-meshheading:11090548-Cells, Cultured,
pubmed-meshheading:11090548-Dogs,
pubmed-meshheading:11090548-Genes, Reporter,
pubmed-meshheading:11090548-Heart Ventricles,
pubmed-meshheading:11090548-Humans,
pubmed-meshheading:11090548-Internet,
pubmed-meshheading:11090548-Ion Transport,
pubmed-meshheading:11090548-Kv1.4 Potassium Channel,
pubmed-meshheading:11090548-Markov Chains,
pubmed-meshheading:11090548-Models, Cardiovascular,
pubmed-meshheading:11090548-Myocardium,
pubmed-meshheading:11090548-Patch-Clamp Techniques,
pubmed-meshheading:11090548-Potassium Channels,
pubmed-meshheading:11090548-Potassium Channels, Voltage-Gated,
pubmed-meshheading:11090548-Reaction Time,
pubmed-meshheading:11090548-Shal Potassium Channels,
pubmed-meshheading:11090548-User-Computer Interface
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pubmed:year |
2000
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pubmed:articleTitle |
Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration.
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pubmed:affiliation |
Department of Biomedical Engineering, Whitaker Biomedical Engineering Institute, the Center for Computational Medicine & Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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