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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-12-19
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pubmed:databankReference |
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pubmed:abstractText |
Antibodies from hyperimmune monkey sera, selected by absorption to Plasmodium falciparum-infected erythrocytes, and elution at acidic pH, allowed us to characterize a novel parasite protein, Pfsbp1 (P. falciparum skeleton binding protein 1). Pfsbp1 is an integral membrane protein of parasite-induced membranous structures associated with the erythrocyte plasma membrane and referred to as Maurer's clefts. The carboxy-terminal domain of Pfsbp1, exposed within the cytoplasm of the host cell, interacts with a 35 kDa erythrocyte skeletal protein and might participate in the binding of the Maurer's clefts to the erythrocyte submembrane skeleton. Antibodies to the carboxy- and amino-terminal domains of Pfsbp1 labelled similar vesicular structures in the cytoplasm of Plasmodium chabaudi and Plasmodium berghei-infected murine erythrocytes, suggesting that the protein is conserved among malaria species, consistent with an important role of Maurer's cleft-like structures in the intraerythrocytic development of malaria parasites.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0166-6851
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11087921-Amino Acid Sequence,
pubmed-meshheading:11087921-Animals,
pubmed-meshheading:11087921-Blood Proteins,
pubmed-meshheading:11087921-Carrier Proteins,
pubmed-meshheading:11087921-Chromatography, Affinity,
pubmed-meshheading:11087921-Cloning, Molecular,
pubmed-meshheading:11087921-Cytoplasmic Vesicles,
pubmed-meshheading:11087921-Erythrocyte Membrane,
pubmed-meshheading:11087921-Erythrocytes,
pubmed-meshheading:11087921-Gene Dosage,
pubmed-meshheading:11087921-Genes, Protozoan,
pubmed-meshheading:11087921-Malaria,
pubmed-meshheading:11087921-Malaria, Falciparum,
pubmed-meshheading:11087921-Membrane Proteins,
pubmed-meshheading:11087921-Mice,
pubmed-meshheading:11087921-Mice, Inbred BALB C,
pubmed-meshheading:11087921-Mice, Inbred C57BL,
pubmed-meshheading:11087921-Molecular Sequence Data,
pubmed-meshheading:11087921-Plasmodium falciparum,
pubmed-meshheading:11087921-Protozoan Proteins,
pubmed-meshheading:11087921-Recombinant Fusion Proteins,
pubmed-meshheading:11087921-Saimiri
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pubmed:year |
2000
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pubmed:articleTitle |
Pfsbp1, a Maurer's cleft Plasmodium falciparum protein, is associated with the erythrocyte skeleton.
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pubmed:affiliation |
Unité de Biologie des Interactions Hôte-Parasite, Institut Pasteur, 25 Rue du Dr. Roux, Paris 75015, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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