Source:http://linkedlifedata.com/resource/pubmed/id/11073098
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2000-11-9
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| pubmed:abstractText |
Chronic ethanol consumption is associated with increased incidence of hepatic and pulmonary infections. To determine if this is correlated with altered macrophage activity, we analyzed the functional properties of cells isolated sequentially from the liver and lung of rats fed a liquid diet containing ethanol (35% of calories) or malto-dextrin control for 9-12 weeks. Hepatic and alveolar macrophages from control animals were found to exhibit distinct morphologic and functional properties. Thus, hepatic macrophages were highly vacuolated and appeared larger and more irregular in shape than alveolar macrophages. These cells also displayed greater phagocytic activity and random migration. In contrast, lung macrophages produced more superoxide anion and nitric oxide, and exhibited enhanced chemotactic activity toward the complement fragment C5a. Whereas administration of ethanol to rats for 9-12 weeks resulted in decreased chemotaxis and superoxide anion production by alveolar macrophages, cell adhesion molecule expression was reduced in hepatic macrophages. Nitric oxide production and inducible nitric oxide synthase protein expression were decreased in both macrophage populations. These effects were not observed after 3-6 weeks of ethanol administration to rats. Our results suggest that changes in macrophage functioning may play a role in decreased host defense following chronic ethanol exposure.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C5a,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
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| pubmed:issn |
0741-5400
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
68
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
614-20
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11073098-Animals,
pubmed-meshheading:11073098-Antigens, CD18,
pubmed-meshheading:11073098-Cell Adhesion,
pubmed-meshheading:11073098-Chemotactic Factors,
pubmed-meshheading:11073098-Chemotaxis,
pubmed-meshheading:11073098-Complement C5a,
pubmed-meshheading:11073098-Diet,
pubmed-meshheading:11073098-Ethanol,
pubmed-meshheading:11073098-Flow Cytometry,
pubmed-meshheading:11073098-Intercellular Adhesion Molecule-1,
pubmed-meshheading:11073098-Liver,
pubmed-meshheading:11073098-Macrophages,
pubmed-meshheading:11073098-Macrophages, Alveolar,
pubmed-meshheading:11073098-Male,
pubmed-meshheading:11073098-Nitrogen,
pubmed-meshheading:11073098-Rats,
pubmed-meshheading:11073098-Rats, Wistar,
pubmed-meshheading:11073098-Reactive Oxygen Species,
pubmed-meshheading:11073098-Tetradecanoylphorbol Acetate,
pubmed-meshheading:11073098-Time Factors
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| pubmed:year |
2000
|
| pubmed:articleTitle |
Functional heterogeneity of rat hepatic and alveolar macrophages: effects of chronic ethanol administration.
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| pubmed:affiliation |
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854-8020, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|