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rdf:type |
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lifeskim:mentions |
umls-concept:C0007613,
umls-concept:C0032214,
umls-concept:C0035820,
umls-concept:C0037083,
umls-concept:C0039194,
umls-concept:C0443288,
umls-concept:C0600138,
umls-concept:C1421249,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1610033,
umls-concept:C1619636,
umls-concept:C1710082
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pubmed:issue |
4
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pubmed:dateCreated |
2000-11-8
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pubmed:abstractText |
Janus kinases (Jaks) play an important role in signal transduction via cytokine receptors. Tyk2 is a Janus kinase, and we developed tyk2-deficient mice to study the requirement for tyk2 in vivo. Tyk2-deficient mice show no overt developmental abnormalities; however, they display a lack of responsiveness to a small amount of IFNalpha, although a high concentration of IFNalpha can fully transduce its signal even in the absence of tyk2. Furthermore, IL-12-induced T cell function is defective in these mice. In contrast, these mice respond normally to IL-6 and IL-10, both of which activate tyk2 in vitro. These observations demonstrate that tyk2 plays only a restricted role in mediating IFNalpha-dependent signaling while being required in mediating IL-12-dependent biological responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:AokiKK,
pubmed-author:BRUCEM AMA,
pubmed-author:GondoHH,
pubmed-author:KatoKK,
pubmed-author:KobayashiSS,
pubmed-author:LaraF YFY,
pubmed-author:MatsudaTT,
pubmed-author:MiyamotoAA,
pubmed-author:NakayamaKK,
pubmed-author:NakayamaTT,
pubmed-author:NumataAA,
pubmed-author:OkamuraSS,
pubmed-author:OkamuraTT,
pubmed-author:SekiguchiKK,
pubmed-author:ShibamoriMM,
pubmed-author:ShibataSS,
pubmed-author:ShimodaKK,
pubmed-author:TakaseKK,
pubmed-author:YamashitaMM
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
561-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11070174-Animals,
pubmed-meshheading:11070174-Embryo, Mammalian,
pubmed-meshheading:11070174-Gene Targeting,
pubmed-meshheading:11070174-Interferon-alpha,
pubmed-meshheading:11070174-Interleukin-10,
pubmed-meshheading:11070174-Interleukin-12,
pubmed-meshheading:11070174-Interleukin-6,
pubmed-meshheading:11070174-Mice,
pubmed-meshheading:11070174-Mice, Inbred Strains,
pubmed-meshheading:11070174-Mice, Knockout,
pubmed-meshheading:11070174-Mutagenesis, Insertional,
pubmed-meshheading:11070174-Protein-Tyrosine Kinases,
pubmed-meshheading:11070174-Proteins,
pubmed-meshheading:11070174-Signal Transduction,
pubmed-meshheading:11070174-Stem Cells,
pubmed-meshheading:11070174-T-Lymphocytes,
pubmed-meshheading:11070174-TYK2 Kinase,
pubmed-meshheading:11070174-Transfection
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pubmed:year |
2000
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pubmed:articleTitle |
Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.
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pubmed:affiliation |
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. kshimoda@intermed1.med.kyushu-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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