| pubmed-article:11067884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11067884 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11067884 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:11067884 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:11067884 | lifeskim:mentions | umls-concept:C0666864 | lld:lifeskim |
| pubmed-article:11067884 | lifeskim:mentions | umls-concept:C1749388 | lld:lifeskim |
| pubmed-article:11067884 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11067884 | lifeskim:mentions | umls-concept:C1882932 | lld:lifeskim |
| pubmed-article:11067884 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11067884 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11067884 | pubmed:dateCreated | 2000-12-11 | lld:pubmed |
| pubmed-article:11067884 | pubmed:abstractText | The Notch ligand, Jagged-1, plays an essential role in tissue formation during embryonic development of primitive organisms. However, little is known regarding the role of Jagged-1 in the regulation of tissue-specific stem cells or its function in humans. Here, we show that uncommitted human hematopoietic cells and cells that comprise the putative blood stem cell microenvironment express Jagged-1 and the Notch receptors. Addition of a soluble form of human Jagged-1 to cultures of purified primitive human blood cells had modest effects in augmenting cytokine-induced proliferation of progenitors. However, intravenous transplantation of cultured cells into immunodeficient mice revealed that human (h)Jagged-1 induces the survival and expansion of human stem cells capable of pluripotent repopulating capacity. Our findings demonstrate that hJagged-1 represents a novel growth factor of human stem cells, thereby providing an opportunity for the clinical utility of Notch ligands in the expansion of primitive cells capable of hematopoietic reconstitution. | lld:pubmed |
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| pubmed-article:11067884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11067884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11067884 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11067884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11067884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11067884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11067884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11067884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11067884 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11067884 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11067884 | pubmed:author | pubmed-author:BhatiaMM | lld:pubmed |
| pubmed-article:11067884 | pubmed:author | pubmed-author:WuD MDM | lld:pubmed |
| pubmed-article:11067884 | pubmed:author | pubmed-author:MurdochBB | lld:pubmed |
| pubmed-article:11067884 | pubmed:author | pubmed-author:SakanoSS | lld:pubmed |
| pubmed-article:11067884 | pubmed:author | pubmed-author:KaranuF NFN | lld:pubmed |
| pubmed-article:11067884 | pubmed:author | pubmed-author:GallacherLL | lld:pubmed |
| pubmed-article:11067884 | pubmed:author | pubmed-author:KoremotoMM | lld:pubmed |
| pubmed-article:11067884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11067884 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:11067884 | pubmed:volume | 192 | lld:pubmed |
| pubmed-article:11067884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11067884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11067884 | pubmed:pagination | 1365-72 | lld:pubmed |
| pubmed-article:11067884 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11067884 | pubmed:meshHeading | pubmed-meshheading:11067884... | lld:pubmed |
| pubmed-article:11067884 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11067884 | pubmed:articleTitle | The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. | lld:pubmed |
| pubmed-article:11067884 | pubmed:affiliation | John P. Robarts Research Institute, Developmental Stem Cell Biology, and the Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada. | lld:pubmed |
