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pubmed:abstractText |
Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in response to a large variety of intrinsic and extrinsic signals.
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pubmed:affiliation |
Department of Oncology/Pathology, Cancer Center Karolinska, Karolinska Insitutet, 17176, Stockholm, Sweden.
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