| pubmed-article:11062604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11062604 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:11062604 | lifeskim:mentions | umls-concept:C0039099 | lld:lifeskim |
| pubmed-article:11062604 | lifeskim:mentions | umls-concept:C0002723 | lld:lifeskim |
| pubmed-article:11062604 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:11062604 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11062604 | pubmed:dateCreated | 2001-1-26 | lld:pubmed |
| pubmed-article:11062604 | pubmed:abstractText | Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA expression was confirmed in all samples obtained from patients with RA, but not in normal synovium. A-SAA mRNA expression was also demonstrated in cultured RA synoviocytes. A-SAA protein was identified in the supernatants of primary synoviocyte cultures, and its expression colocalized with sites of macrophage accumulation and with some vascular endothelial cells. It is concluded that A-SAA is produced by inflamed RA synovial tissue. The known association between the acute-phase response and progressive joint damage may be the direct result of synovial A-SAA-induced effects on cartilage degradation. | lld:pubmed |
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| pubmed-article:11062604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11062604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11062604 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11062604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11062604 | pubmed:issn | 1465-9905 | lld:pubmed |
| pubmed-article:11062604 | pubmed:author | pubmed-author:FitzGeraldOO | lld:pubmed |
| pubmed-article:11062604 | pubmed:author | pubmed-author:BresnihanBB | lld:pubmed |
| pubmed-article:11062604 | pubmed:author | pubmed-author:WhiteheadA... | lld:pubmed |
| pubmed-article:11062604 | pubmed:author | pubmed-author:O'HaraRR | lld:pubmed |
| pubmed-article:11062604 | pubmed:author | pubmed-author:MurphyE PEP | lld:pubmed |
| pubmed-article:11062604 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11062604 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:11062604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11062604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11062604 | pubmed:pagination | 142-4 | lld:pubmed |
| pubmed-article:11062604 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11062604 | pubmed:meshHeading | pubmed-meshheading:11062604... | lld:pubmed |
| pubmed-article:11062604 | pubmed:meshHeading | pubmed-meshheading:11062604... | lld:pubmed |
| pubmed-article:11062604 | pubmed:meshHeading | pubmed-meshheading:11062604... | lld:pubmed |
| pubmed-article:11062604 | pubmed:meshHeading | pubmed-meshheading:11062604... | lld:pubmed |
| pubmed-article:11062604 | pubmed:meshHeading | pubmed-meshheading:11062604... | lld:pubmed |
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| pubmed-article:11062604 | pubmed:meshHeading | pubmed-meshheading:11062604... | lld:pubmed |
| pubmed-article:11062604 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11062604 | pubmed:articleTitle | Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue. | lld:pubmed |
| pubmed-article:11062604 | pubmed:affiliation | St Vincent's University Hospital, Dublin, Ireland. | lld:pubmed |
| pubmed-article:11062604 | pubmed:publicationType | Journal Article | lld:pubmed |
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