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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-1-26
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pubmed:abstractText |
Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA expression was confirmed in all samples obtained from patients with RA, but not in normal synovium. A-SAA mRNA expression was also demonstrated in cultured RA synoviocytes. A-SAA protein was identified in the supernatants of primary synoviocyte cultures, and its expression colocalized with sites of macrophage accumulation and with some vascular endothelial cells. It is concluded that A-SAA is produced by inflamed RA synovial tissue. The known association between the acute-phase response and progressive joint damage may be the direct result of synovial A-SAA-induced effects on cartilage degradation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-10229397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-10648018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-1329776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-1626285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-1656519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-1849144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-2271017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-3358796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-7516407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-7516430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-8080047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-8155266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-8159722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-8817153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-8914601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-9315118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-9605178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-9790312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062604-9815279
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-9905
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
142-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue.
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pubmed:affiliation |
St Vincent's University Hospital, Dublin, Ireland.
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pubmed:publicationType |
Journal Article
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