Source:http://linkedlifedata.com/resource/pubmed/id/11058789
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-11-17
|
| pubmed:abstractText |
Recent reports have suggested that genetic polymorphisms in the alpha-2 macroglobulin (A2M) gene are associated with an increased risk for Alzheimer's disease. In the present study we tested two polymorphisms in the alpha-2 macroglobulin gene, a 5 bp deletion at the 5' splice site of exon 18 and a G/A point mutation (V1000I) in exon 24, in a sample of 118 healthy, non demented controls and 238 consecutively recruited gerontopsychiatric patients, diagnosed as: Alzheimer's disease (N=88), mild cognitive impairment (N=32), subjective cognitive complaints (N=54) and depression/other psychiatric disorders (N=64). The aim of this study was to test whether the investigated polymorphisms has a high enough selectivity and specificity to distinguish between the different gerontopsychiatric disorders or to differentiate genetically AD from other forms of dementia, respectively. Also a possible relation to the APOE varepsilon4 polymorphism was examined. Our study failed to show an association between the two investigated polymorphisms in the alpha-2 macroglobulin gene and any of the four different psychogeriatric patient subgroups, either alone or in combination with the APOE varepsilon4 genotype.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0304-3940
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
17
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| pubmed:volume |
294
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
69-72
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:11058789-Aged,
pubmed-meshheading:11058789-Alleles,
pubmed-meshheading:11058789-Alzheimer Disease,
pubmed-meshheading:11058789-Apolipoprotein E4,
pubmed-meshheading:11058789-Apolipoproteins E,
pubmed-meshheading:11058789-Case-Control Studies,
pubmed-meshheading:11058789-Cognition Disorders,
pubmed-meshheading:11058789-Depression,
pubmed-meshheading:11058789-Diagnosis, Differential,
pubmed-meshheading:11058789-European Continental Ancestry Group,
pubmed-meshheading:11058789-Female,
pubmed-meshheading:11058789-Gene Frequency,
pubmed-meshheading:11058789-Genetic Testing,
pubmed-meshheading:11058789-Genotype,
pubmed-meshheading:11058789-Germany,
pubmed-meshheading:11058789-Humans,
pubmed-meshheading:11058789-Male,
pubmed-meshheading:11058789-Middle Aged,
pubmed-meshheading:11058789-Polymorphism, Genetic,
pubmed-meshheading:11058789-Predictive Value of Tests,
pubmed-meshheading:11058789-Sensitivity and Specificity,
pubmed-meshheading:11058789-alpha-Macroglobulins
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients.
|
| pubmed:affiliation |
Psychiatric Hospital of the Ludwig-Maximilians-University, Munich, Nussbaumstrasse 7, D-80336, Munich, Germany. peter.zill@psy.med.uni-muenchen.de
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|