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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2001-2-20
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pubmed:abstractText |
Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into 'permissive' and 'nonpermissive' regions and led to the discovery of new nodulisporamides with significantly improved flea efficacy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BaerD BDB,
pubmed-author:CollettiS LSL,
pubmed-author:FisherM HMH,
pubmed-author:INGH RHR,
pubmed-author:LinKK,
pubmed-author:MAJJ,
pubmed-author:MeinkeP TPT,
pubmed-author:SalvoMM,
pubmed-author:SchmitzL MLM,
pubmed-author:ShoopW LWL,
pubmed-author:ShyuL YLY,
pubmed-author:WarmkeL MLM,
pubmed-author:WyvrattM JMJ,
pubmed-author:Zakson-AikenMM
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2371-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
Chemical modification of nodulisporic acid A: preliminary structure-activity relationships.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. peter_meinke@merck.com
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pubmed:publicationType |
Journal Article
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