Linked Life Data

11048764

Source:http://linkedlifedata.com/resource/pubmed/id/11048764

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-1-18
pubmed:abstractText
Asthma is one of the atopic diseases strongly associated with allergy. High aeroallergen exposure in the immediate postnatal period has been associated with higher risk of sensitization and chronic asthma. It is proposed that following in utero allergen sensitization, postnatal high dose allergen exposure localizes inflammation to the airways. In association with adjuvantizing effects of some virus infections, eosinophils and neutrophils are recruited which contribute to epithelial damage and the initiation of the remodelling process. Eventually, the latter processes lead to sufficient airway narrowing to manifest as the first symptoms of asthma. Thus, the immunopathology of asthma is fully established by the time of first symptoms and future strategies will need to identify those at risk of developing the disease before irreversible changes in the airways are established.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0905-6157
pubmed:author
pubmed:issnType
Print
pubmed:volume
11 Suppl 13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-4
pubmed:dateRevised
2008-5-28
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Progression from allergic sensitization to asthma.
pubmed:affiliation
Child Health, University of Southampton/Southampton General Hospital, UK. jow@soton.ac.uk
pubmed:publicationType
Journal Article