Linked Life Data

11045970

Source:http://linkedlifedata.com/resource/pubmed/id/11045970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-11-17
pubmed:abstractText
To clarify the physiology of venous return (Q(vr)) in Fontan circulations, venous return conductance (G(vr)) and mean circulatory filling pressure (P(mcf)) were determined in pentobarbital sodium-anesthetized pigs. Relationships between Q(vr) and right (biventricular, n = 8) or left (Fontan, n = 8) filling pressures are described by straight lines with significant correlation coefficients. Estimated P(mcf) values were correlated with observed P(mcf) values in either circulations (P </= 0.02). G(vr) was smaller in Fontan than in biventricular circulations (4.51 +/- 0.36 vs. 7.83 +/- 0.69 ml. min(-1). kg(-1). mmHg(-1), P = 0.002) and inversely correlated with pulmonary vascular resistances in Fontan circulations (P = 0.01). Estimated P(mcf) (20.5 +/- 1.4 vs. 11.1 +/- 0.9 mmHg, P = 0.001) and observed P(mcf) (21.8 +/- 1.3 vs. 10.6 +/- 0.8 mmHg, P < 0.001) were higher in Fontan versus biventricular circulations, respectively. Pulmonary artery pressure in Fontan circulations was correlated with either P(mcf) (P < or = 0.04). We conclude that in Fontan circulations 1) pulmonary vascular resistances induce a proportional decrease in G(vr); and 2) volume loading, while increasing P(mcf) (similar to pulmonary artery pressure), allows the gradient for Q(vr) to increase and maintains systemic blood flow at a biventricular level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0363-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
279
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H2335-43
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Changes in venous return parameters associated with univentricular Fontan circulations.
pubmed:affiliation
Department of Cardiovascular and Pediatric Cardiac Surgery and Experimental Surgical Laboratory, Marie Lannelongue Hospital, Paris-Sud University, 92350 Le Plessis Robinson, France. mace@ccml.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't