|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2000-11-7
|
|
pubmed:abstractText |
p16(INK4a) is a cell cycle inhibitor and a major tumor-suppressor protein, but the regulation of p16(INK4a) is poorly understood and the physiologic settings in which it exerts its antiproliferative effects are unknown. A role for p16(INK4a) in intestinal neoplasia is suggested by the observation that the promoter region is methylated in a subset of human colon tumors. We examined the expression of the protein in specimens representing the full spectrum of neoplastic progression in the human colon and determined whether expressing cells showed evidence of cell cycle inhibition.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0016-5085
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
119
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
929-42
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:11040180-Blotting, Western,
pubmed-meshheading:11040180-Carrier Proteins,
pubmed-meshheading:11040180-Cell Division,
pubmed-meshheading:11040180-Cell Membrane,
pubmed-meshheading:11040180-Colonic Neoplasms,
pubmed-meshheading:11040180-Cyclin-Dependent Kinase 4,
pubmed-meshheading:11040180-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:11040180-Cyclin-Dependent Kinases,
pubmed-meshheading:11040180-Humans,
pubmed-meshheading:11040180-Immunohistochemistry,
pubmed-meshheading:11040180-Intestinal Mucosa,
pubmed-meshheading:11040180-Proto-Oncogene Proteins,
pubmed-meshheading:11040180-Rectal Neoplasms,
pubmed-meshheading:11040180-Retinoblastoma Protein,
pubmed-meshheading:11040180-Reverse Transcriptase Polymerase Chain Reaction
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation.
|
|
pubmed:affiliation |
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
