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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1976-1-23
|
| pubmed:abstractText |
The first fetal cells synthesizing Ig can be demonstrated at day 10 of gesta tion, well before cells with detectable surface-bound Ig have been found. These early Ig-synthesizing cells are exclusively large cells. The first small cells synthesizing Ig appear at day 15-16 of gestation, a time when cells. with detectable surface-bound Ig have been found in fetal liver. Ig synthesis of liver cells declines 2 days after birth, presumably reflecting a change in cellular composition of the liver, whereas spleen cells, on a per cell basis, synthesize Ig at a constant rate from birth to adult life. At the time that the first small Ig-synthesizing cells are detected and surface-bound Ig has been found on fetal liver cells, such small fetal liver cells can be stimulated by LPS in serum-containing media to generate 19S IgM secreting PFC. Three to four days after birth, cells develop in the small fraction of spleen which can be stimulated in serum-free media by either LPS or PPD to PFC development. Thus we can distinguish three types of B-lymphocytes as they appear sequentially during ontogeny: I. Large, Ig-producing cells, not susceptible to polyclonal activation to PFC development by either LPS or PPD. II. Small, Ig-producing cells, susceptible to LPS-stimulation in serum-containing media; and III. Small, Ig-producing cells, susceptible to LPC- and PPD-stimulation in serum-free media.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0082-5948
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
26-58
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:1103381-Animals,
pubmed-meshheading:1103381-Antibodies, Anti-Idiotypic,
pubmed-meshheading:1103381-Antibody Formation,
pubmed-meshheading:1103381-B-Lymphocytes,
pubmed-meshheading:1103381-Biological Evolution,
pubmed-meshheading:1103381-Bone Marrow,
pubmed-meshheading:1103381-Bone Marrow Cells,
pubmed-meshheading:1103381-Cells, Cultured,
pubmed-meshheading:1103381-Fetus,
pubmed-meshheading:1103381-Immunoglobulin M,
pubmed-meshheading:1103381-Liver,
pubmed-meshheading:1103381-Lymph,
pubmed-meshheading:1103381-Lymph Nodes,
pubmed-meshheading:1103381-Lymphocyte Activation,
pubmed-meshheading:1103381-Mice,
pubmed-meshheading:1103381-Mice, Inbred BALB C,
pubmed-meshheading:1103381-Mice, Nude,
pubmed-meshheading:1103381-Mitogens,
pubmed-meshheading:1103381-Spleen,
pubmed-meshheading:1103381-Thoracic Duct
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
B-lymphocyte subpopulations in the mouse. Organ distribution and ontogeny of immunoglobulin-synthesizing and of mitogen-sensitive cells.
|
| pubmed:publicationType |
Journal Article,
Review
|