In semen, prostate-specific antigen (PSA or hK3) digests the gel proteins semenogelin I and II, resulting in liquefaction and the release of motile spermatozoa. We characterized the substrate specificity and zinc-mediated inhibition of PSA.
Section for Clinical Chemistry, Department of Laboratory Medicine, Lund University, University Hospital Malmö, Malmö, Sweden. johan.malm@klkemi.mas.lu.se