Linked Life Data

11027248

Source:http://linkedlifedata.com/resource/pubmed/id/11027248

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2000-10-16
pubmed:abstractText
We investigated a role for cAMP/protein kinase A (PKA) in light/glutamate (GLU)-stimulated state changes of the mammalian circadian clock in the suprachiasmatic nucleus (SCN). Nocturnal GLU treatment elevated [cAMP]; however, agonists of cAMP/PKA did not mimic the effects of light/GLU. Coincident activation of cAMP/PKA enhanced GLU-stimulated state changes in early night but blocked light/GLU-induced state changes in the late night, whereas inhibition of cAMP/PKA reversed these effects. These responses are distinct from those mediated by mitogen-activated protein kinase (MAPK). MAPK inhibitors attenuated both GLU-induced state changes. Although GLU induced mPer1 mRNA in both early and late night, inhibition of PKA blocked this event only in early night, suggesting that cellular mechanisms regulating mPer1 are gated by the suprachiasmatic circadian clock. These data support a diametric gating role for cAMP/PKA in light/GLU-induced SCN state changes: cAMP/PKA promotes the effects of light/GLU in early night, but opposes them in late night.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7830-7
pubmed:dateRevised
2010-8-10
pubmed:meshHeading
pubmed-meshheading:11027248-Animals, pubmed-meshheading:11027248-Biological Clocks, pubmed-meshheading:11027248-Cell Cycle Proteins, pubmed-meshheading:11027248-Circadian Rhythm, pubmed-meshheading:11027248-Cyclic AMP, pubmed-meshheading:11027248-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:11027248-Darkness, pubmed-meshheading:11027248-Enzyme Inhibitors, pubmed-meshheading:11027248-Glutamic Acid, pubmed-meshheading:11027248-Light, pubmed-meshheading:11027248-Mitogen-Activated Protein Kinases, pubmed-meshheading:11027248-Nuclear Proteins, pubmed-meshheading:11027248-Period Circadian Proteins, pubmed-meshheading:11027248-Photic Stimulation, pubmed-meshheading:11027248-RNA, Messenger, pubmed-meshheading:11027248-Rats, pubmed-meshheading:11027248-Rats, Long-Evans, pubmed-meshheading:11027248-Reaction Time, pubmed-meshheading:11027248-Signal Transduction, pubmed-meshheading:11027248-Suprachiasmatic Nucleus
pubmed:year
2000
pubmed:articleTitle
Differential cAMP gating of glutamatergic signaling regulates long-term state changes in the suprachiasmatic circadian clock.
pubmed:affiliation
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.