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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2000-12-19
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pubmed:databankReference |
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pubmed:abstractText |
Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and OT7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1465-7392
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pubmed:author |
pubmed-author:AsadaMM,
pubmed-author:FujiiRR,
pubmed-author:FujinoMM,
pubmed-author:FukusumiSS,
pubmed-author:HabataYY,
pubmed-author:HinumaSS,
pubmed-author:HosoyaMM,
pubmed-author:IbataYY,
pubmed-author:IijimaNN,
pubmed-author:KawamataYY,
pubmed-author:KikuchiKK,
pubmed-author:KitadaCC,
pubmed-author:KurokawaTT,
pubmed-author:MatsumotoYY,
pubmed-author:NEELH BHB,
pubmed-author:NishimuraOO,
pubmed-author:ShintaniYY,
pubmed-author:TanakaMM,
pubmed-author:TeraoYY,
pubmed-author:WatanabeTT,
pubmed-author:YamamotoTT,
pubmed-author:YanoTT
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
703-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11025660-Amino Acid Sequence,
pubmed-meshheading:11025660-Animals,
pubmed-meshheading:11025660-Cattle,
pubmed-meshheading:11025660-Cloning, Molecular,
pubmed-meshheading:11025660-Humans,
pubmed-meshheading:11025660-Mice,
pubmed-meshheading:11025660-Molecular Sequence Data,
pubmed-meshheading:11025660-Neuropeptides,
pubmed-meshheading:11025660-Rats,
pubmed-meshheading:11025660-Receptors, Neuropeptide,
pubmed-meshheading:11025660-Sequence Homology, Amino Acid,
pubmed-meshheading:11025660-Species Specificity
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pubmed:year |
2000
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pubmed:articleTitle |
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
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pubmed:affiliation |
Pharmaceutical Discovery Research Division, Takeda Chemical Industries Ltd., 10 Wadai, Tsukuba, Ibaraki 300-4293, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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