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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-11-8
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089087,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089088,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089089,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089090,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089091,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089092,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089093,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089094,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089095,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF089096,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF158748,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF200349,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF300795
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pubmed:abstractText |
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:BaierL JLJ,
pubmed-author:BoerwinkleEE,
pubmed-author:BogardusCC,
pubmed-author:COLEL JLJ,
pubmed-author:ColillaSS,
pubmed-author:ConcannonPP,
pubmed-author:CoxN JNJ,
pubmed-author:GroopLL,
pubmed-author:HanisC LCL,
pubmed-author:HaraMM,
pubmed-author:HinokioYY,
pubmed-author:HorikawaYY,
pubmed-author:IwasakiNN,
pubmed-author:LULL,
pubmed-author:LindnerT HTH,
pubmed-author:MashimaHH,
pubmed-author:OdaYY,
pubmed-author:Orho-MelanderMM,
pubmed-author:PolonskyK SKS,
pubmed-author:ROT KTK,
pubmed-author:SchulzeJJ,
pubmed-author:SchwarzP EPE,
pubmed-author:WeiSS,
pubmed-author:YoshiuchiII,
pubmed-author:del Bosque-PlataLL
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-75
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11017071-Adult,
pubmed-meshheading:11017071-Amino Acid Sequence,
pubmed-meshheading:11017071-Calpain,
pubmed-meshheading:11017071-Chromosome Mapping,
pubmed-meshheading:11017071-Chromosomes, Human, Pair 2,
pubmed-meshheading:11017071-Diabetes Mellitus, Type 2,
pubmed-meshheading:11017071-European Continental Ancestry Group,
pubmed-meshheading:11017071-Finland,
pubmed-meshheading:11017071-Gene Frequency,
pubmed-meshheading:11017071-Genetic Markers,
pubmed-meshheading:11017071-Genetic Predisposition to Disease,
pubmed-meshheading:11017071-Genetic Variation,
pubmed-meshheading:11017071-Genome, Human,
pubmed-meshheading:11017071-Haplotypes,
pubmed-meshheading:11017071-Humans,
pubmed-meshheading:11017071-Mexican Americans,
pubmed-meshheading:11017071-Molecular Sequence Data,
pubmed-meshheading:11017071-Polymorphism, Genetic,
pubmed-meshheading:11017071-Risk Assessment,
pubmed-meshheading:11017071-United States
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pubmed:year |
2000
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pubmed:articleTitle |
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
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pubmed:affiliation |
Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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