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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2001-1-3
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pubmed:abstractText |
2'-Deoxyguanosine residues of a 3',5'-end-modified hexadeoxyribonucleotide (R-95288) with anti-HIV-1 activity were substituted with N2-methyl-2'-deoxyguanosine (m2dG). These modified oligodeoxyribonucleotides (ODNs) showed a 2-fold higher activity than R-95288. Also, the CD spectra of these ODNs indicated that the m2dG modification stabilized the tertiary structure of the G-quadruplex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2213-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11012032-Anti-HIV Agents,
pubmed-meshheading:11012032-Cell Line,
pubmed-meshheading:11012032-Circular Dichroism,
pubmed-meshheading:11012032-Deoxyguanosine,
pubmed-meshheading:11012032-Drug Evaluation, Preclinical,
pubmed-meshheading:11012032-HIV-1,
pubmed-meshheading:11012032-Humans,
pubmed-meshheading:11012032-Methylation,
pubmed-meshheading:11012032-Molecular Structure,
pubmed-meshheading:11012032-Nucleic Acid Conformation,
pubmed-meshheading:11012032-Oligodeoxyribonucleotides
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pubmed:year |
2000
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pubmed:articleTitle |
Biologically active oligodeoxyribonucleotides. Part 12: N2-methylation of 2'-deoxyguanosines enhances stability of parallel G-quadruplex and anti-HIV-1 activity.
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pubmed:affiliation |
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd, Tokyo, Japan. koizum@shina.sankyo.co.jp
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pubmed:publicationType |
Journal Article
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