Linked Life Data

11008907

Source:http://linkedlifedata.com/resource/pubmed/id/11008907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2001-1-3
pubmed:abstractText
Heterocyclic amines found in well-done meat require host-mediated metabolic activation before initiating DNA mutations and tumors in target organs. Polymorphic N-acetyltransferase-2 (NAT2) catalyzes the activation of heterocyclic amines via O-acetylation, suggesting that NAT2 genotypes with high O-acetyltransferase activity (rapid/intermediate acetylator phenotype) increase the risk of breast cancer in women who consume well-done meat. To test this hypothesis, DNA samples and information on diet and other breast cancer risk factors were obtained from a nested case-control study of postmenopausal women. Twenty-seven NAT2 genotypes were determined and assigned to rapid, intermediate, or slow acetylator groups based on published characterizations of recombinant NAT2 allozymes. NAT2 genotype alone was not associated with breast cancer risk. A significant dose-response relationship was observed between breast cancer risk and consumption of well-done meat among women with the rapid/intermediate NAT2 genotype (trend test, P = 0.003) that was not evident among women with the slow acetylator genotype (trend test, P = 0.22). These results suggest an interaction between NAT2 genotype and meat doneness, although a test for multiplicative interaction was not statistically significant (P = 0.06). Among women with the rapid/intermediate NAT2 genotype, consumption of well-done meat was associated with a nearly 8-fold (odds ratio, 7.6; 95% confidence interval, 1.1-50.4) elevated breast cancer risk compared with those consuming rare or medium-done meats. These results are consistent with a role for O-acetylation in the activation of heterocyclic amine carcinogens and support the hypothesis that the NAT2 acetylation polymorphism is a breast cancer risk factor among postmenopausal women with high levels of heterocyclic amine exposure.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
905-10
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11008907-Acetylation, pubmed-meshheading:11008907-Aged, pubmed-meshheading:11008907-Amines, pubmed-meshheading:11008907-Arylamine N-Acetyltransferase, pubmed-meshheading:11008907-Biotransformation, pubmed-meshheading:11008907-Breast Neoplasms, pubmed-meshheading:11008907-Carcinogens, pubmed-meshheading:11008907-Case-Control Studies, pubmed-meshheading:11008907-Cooking, pubmed-meshheading:11008907-Female, pubmed-meshheading:11008907-Heterocyclic Compounds, pubmed-meshheading:11008907-Humans, pubmed-meshheading:11008907-Likelihood Functions, pubmed-meshheading:11008907-Logistic Models, pubmed-meshheading:11008907-Meat, pubmed-meshheading:11008907-Middle Aged, pubmed-meshheading:11008907-Odds Ratio, pubmed-meshheading:11008907-Polymorphism, Restriction Fragment Length, pubmed-meshheading:11008907-Polymorphism, Single Nucleotide, pubmed-meshheading:11008907-Postmenopause, pubmed-meshheading:11008907-Risk Factors
pubmed:year
2000
pubmed:articleTitle
N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women.
pubmed:affiliation
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Kentucky 40292, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't