|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2000-10-12
|
|
pubmed:abstractText |
It was recently shown that phosphatidylinositol-(PI)3 kinase is upregulated in wounded rabbit corneal epithelia. Extracellular signal-regulated kinase (erk)-1 and -2 proteins and PI-3 kinase were activated in embryonic corneal epithelia after 1-hour stimulation by type I collagen. In the current investigation specific inhibitors of PI-3 kinase and mitogen-activated kinase-kinase (MEK-1 kinase) were used to determine the role of these signaling molecules in actin reorganization and collagen binding to isolated sheets of corneal epithelial tissue.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10096665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10096666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10209147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10209154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10209156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10212207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10446041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10549641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-10559899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-1740362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-2503524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-3517010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-3653519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-7197682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-7499206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-7542246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-7716514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-7834746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-7868907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-7929388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-7937853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-8106507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-8308054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-8792086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-9034330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-9069255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-9214622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11006227-9788874
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0146-0404
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
41
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3374-82
|
|
pubmed:dateRevised |
2011-5-4
|
|
pubmed:meshHeading |
pubmed-meshheading:11006227-Actins,
pubmed-meshheading:11006227-Animals,
pubmed-meshheading:11006227-Blotting, Western,
pubmed-meshheading:11006227-Chick Embryo,
pubmed-meshheading:11006227-Chromones,
pubmed-meshheading:11006227-Collagen,
pubmed-meshheading:11006227-Dose-Response Relationship, Drug,
pubmed-meshheading:11006227-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:11006227-Enzyme Inhibitors,
pubmed-meshheading:11006227-Epithelium, Corneal,
pubmed-meshheading:11006227-Extracellular Matrix,
pubmed-meshheading:11006227-Flavonoids,
pubmed-meshheading:11006227-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:11006227-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:11006227-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11006227-Morpholines,
pubmed-meshheading:11006227-Organ Culture Techniques,
pubmed-meshheading:11006227-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:11006227-Phosphorylation,
pubmed-meshheading:11006227-Signal Transduction
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Erk and PI-3 kinase are necessary for collagen binding and actin reorganization in corneal epithelia.
|
|
pubmed:affiliation |
Departments of Anatomy and Neurobiology and. Pathology, Boston University School of Medicine, Massachusetts, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
