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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0013139,
umls-concept:C0162326,
umls-concept:C0185023,
umls-concept:C0237497,
umls-concept:C0441712,
umls-concept:C1314972,
umls-concept:C1709305,
umls-concept:C1947904,
umls-concept:C1999228,
umls-concept:C2825781
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pubmed:issue |
20
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pubmed:dateCreated |
2000-10-30
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pubmed:abstractText |
Drosophila telomeres contain arrays of the retrotransposonlike elements HeT-A and TART. Their transposition to broken chromosomal termini has been implicated in chromosome healing and telomere elongation. The HeT-A element is attached by its 3' end, which contains the promoter. To monitor the behavior of HeT-A elements, we used the yellow gene with terminal deficiencies consisting of breaks in the yellow promoter region that result in the y-null phenotype. Attachment of the HeT-A element provides the promoterless yellow gene with a promoter that activates yellow expression in bristles. The frequency of HeT-A transpositions to the yellow terminal deficiency depends on the genotype of the line and varies from 2 x 10(-3) to less than 2 x 10(-5). Loss of the attached HeT-A due to incomplete replication at the telomere leads to inactivation of yellow expression, which is restored by attachment of a new HeT-A element upstream of yellow. New HeT-A additions occur at a frequency of about 1.2 x 10(-3). Short DNA attachments are generated by gene conversion using the homologous telomeric sequences as templates. Longer DNA attachments are generated either by conventional transposition of an HeT-A element to the chromosomal terminus or by recombination between the 3' terminus of telomeric HeT-A elements and the receding end of HeT-A attached to the yellow gene.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-10382069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-10382073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-10500091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-1324409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-1330538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-1501251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-2111466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-2111731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-2308935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-2536898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-2548737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-2550760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-2841109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-3096713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-3123324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-3141921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-7556065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-7716808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-7809068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8261510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8387212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8524329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8647430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8668143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8698241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8811183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8851970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-8995054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9054504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9148955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9175740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9178008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9215555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9271395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9335332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9419332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9459432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9475735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9520442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9524751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9799256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11003659-9858610
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7634-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11003659-Animals,
pubmed-meshheading:11003659-Base Sequence,
pubmed-meshheading:11003659-DNA,
pubmed-meshheading:11003659-DNA Replication,
pubmed-meshheading:11003659-Drosophila Proteins,
pubmed-meshheading:11003659-Drosophila melanogaster,
pubmed-meshheading:11003659-Gene Conversion,
pubmed-meshheading:11003659-Gene Expression,
pubmed-meshheading:11003659-Genotype,
pubmed-meshheading:11003659-Insect Proteins,
pubmed-meshheading:11003659-Molecular Sequence Data,
pubmed-meshheading:11003659-Phenotype,
pubmed-meshheading:11003659-Promoter Regions, Genetic,
pubmed-meshheading:11003659-Restriction Mapping,
pubmed-meshheading:11003659-Retroelements,
pubmed-meshheading:11003659-Sequence Deletion,
pubmed-meshheading:11003659-Sequence Homology, Nucleic Acid,
pubmed-meshheading:11003659-Telomere,
pubmed-meshheading:11003659-Transcriptional Activation
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pubmed:year |
2000
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pubmed:articleTitle |
Attachment of HeT-A sequences to chromosomal termini in Drosophila melanogaster may occur by different mechanisms.
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pubmed:affiliation |
Department of Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 117334 Moscow, Russia.
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pubmed:publicationType |
Journal Article
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