Source:http://linkedlifedata.com/resource/pubmed/id/11001164
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2000-12-26
|
| pubmed:abstractText |
Systemic endotoxemia develops during cardiopulmonary bypass, probably due to intestinal ischaemia. Differences in endotoxaemia among various cardiac operations and the relationship between endotoxemia and postoperative complications were studied in high-risk patients. Blood samples were obtained at termination of bypass in 136 adults undergoing elective cardiac surgery. Postoperative complications were registered prospectively. Plasma endotoxin was quantified by a kinetic limulus amebocyte lysate assay. Mean endotoxin concentrations were significantly lower in patients undergoing isolated valve replacement (89 ng/l) than in patients undergoing coronary artery bypass grafting alone (234 ng/l), or combined with valve replacement (278 ng/l) or carotid artery surgery (321 ng/l) (p < 0.05). In multivariate linear regression, only the number of grafts (0, 1-3, 4-5) was significantly correlated to endotoxin concentrations (p < 0.0005). Endotoxin concentrations were related to development of gastrointestinal dysfunction (p = 0.03), but not to mortality (p = 0.24) or other complications (p = 0.62).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0267-6591
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
421-6
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11001164-Aged,
pubmed-meshheading:11001164-Arteriosclerosis,
pubmed-meshheading:11001164-Blood Vessel Prosthesis Implantation,
pubmed-meshheading:11001164-Cardiac Surgical Procedures,
pubmed-meshheading:11001164-Cardiopulmonary Bypass,
pubmed-meshheading:11001164-Carotid Arteries,
pubmed-meshheading:11001164-Endotoxins,
pubmed-meshheading:11001164-Female,
pubmed-meshheading:11001164-Gastrointestinal Diseases,
pubmed-meshheading:11001164-Heart Valve Prosthesis Implantation,
pubmed-meshheading:11001164-Humans,
pubmed-meshheading:11001164-Ischemia,
pubmed-meshheading:11001164-Limulus Test,
pubmed-meshheading:11001164-Male,
pubmed-meshheading:11001164-Middle Aged,
pubmed-meshheading:11001164-Multivariate Analysis,
pubmed-meshheading:11001164-Postoperative Complications,
pubmed-meshheading:11001164-Prospective Studies
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Plasma endotoxin concentrations during cardiac surgery may be related to atherosclerosis.
|
| pubmed:affiliation |
Department of Surgery A, Institute for Surgical Research. vibeke.videm@medisin.ntnu.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|