Linked Life Data

10996361

Source:http://linkedlifedata.com/resource/pubmed/id/10996361

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-11-15
pubmed:abstractText
We have quantified levels of CD105, its ligand TGFbeta and receptor-ligand complexes in sera from healthy individuals (n=31), patients with triple vessel disease documented by coronary angiography (TVD; n=36) and patients with chest pain and a positive exercise electrocardiogram but with normal coronary angiogram (NCA; n=30). Both active TGFbeta1 and active plus acid-activatable TGFbeta1 [(a+l)TGFbeta1] were significantly depressed in patients with TVD compared with the other two groups (P</=0.04). CD105 levels in TVD patients were also diminished but elevated in NCA patients. In contrast, patients with TVD had more CD105/TGFbeta1 complex in their sera than the other two groups, suggesting that this may be the reason why TVD patients had low levels of receptor and ligand. TGFbeta3 levels were similar in the three groups, but elevated CD105/TGFbeta3 levels were noted in patients with NCA compared with those with TVD and healthy individuals (P< or =0.02). CD105 was correlated with both active TGFbeta1 and (a+l)TGFbeta1 (P=0.02). CD105 also strongly correlated with TGFbeta3 and CD105/TGFbeta3 complexes (P=0.001 in both cases). The changes in levels of CD105, TGFbeta1 and the receptor-ligand complexes in sera of patients with atherosclerosis suggest that these molecules may be important in the pathobiology of the atherosclerotic disease. Further studies on sequential samples from a larger cohort of patients are needed to define a causal relationship between these molecules and the disease progression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10996361-Aged, pubmed-meshheading:10996361-Angina Pectoris, pubmed-meshheading:10996361-Antigen-Antibody Complex, pubmed-meshheading:10996361-Antigens, CD, pubmed-meshheading:10996361-Biological Markers, pubmed-meshheading:10996361-Coronary Angiography, pubmed-meshheading:10996361-Coronary Disease, pubmed-meshheading:10996361-Electrocardiography, pubmed-meshheading:10996361-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:10996361-Female, pubmed-meshheading:10996361-Humans, pubmed-meshheading:10996361-Male, pubmed-meshheading:10996361-Middle Aged, pubmed-meshheading:10996361-Probability, pubmed-meshheading:10996361-Prognosis, pubmed-meshheading:10996361-Radioimmunoassay, pubmed-meshheading:10996361-Receptors, Cell Surface, pubmed-meshheading:10996361-Reference Values, pubmed-meshheading:10996361-Sensitivity and Specificity, pubmed-meshheading:10996361-Signal Transduction, pubmed-meshheading:10996361-Statistics, Nonparametric, pubmed-meshheading:10996361-Transforming Growth Factor beta, pubmed-meshheading:10996361-Vascular Cell Adhesion Molecule-1
pubmed:year
2000
pubmed:articleTitle
The significance of CD105, TGFbeta and CD105/TGFbeta complexes in coronary artery disease.
pubmed:affiliation
Department of Pathological Sciences, Medical School, The University, M13 9PT, Manchester, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial, Research Support, Non-U.S. Gov't