| pubmed-article:10993782 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10993782 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:10993782 | lifeskim:mentions | umls-concept:C1622418 | lld:lifeskim |
| pubmed-article:10993782 | lifeskim:mentions | umls-concept:C0031671 | lld:lifeskim |
| pubmed-article:10993782 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:10993782 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:10993782 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10993782 | pubmed:dateCreated | 2000-10-12 | lld:pubmed |
| pubmed-article:10993782 | pubmed:abstractText | Cardiac sarcolemmal Na(+)/H(+) exchange is critical for the regulation of intracellular pH, and its activity contributes to ischemia-reperfusion injury. It has been suggested that the membrane phospholipid environment does not modulate Na(+)/H(+) exchange. The present study was carried out to determine the effects on Na(+)/H(+) exchange of modifying the endogenous membrane phospholipids through the addition of exogenous phospholipase D. Incubation of 0.825 U of phospholipase D with 1 mg of porcine cardiac sarcolemmal vesicles hydrolyzed 34 +/- 2% of the sarcolemmal phosphatidylcholine and increased phosphatidic acid 10.2 +/- 0.5-fold. Treatment of vesicles with phospholipase D resulted in a 46 +/- 2% inhibition of Na(+)/H(+) exchange. Na(+)/H(+) exchange was measured as a function of reaction time, extravesicular pH, and extravesicular Na(+). All of these parameters of Na(+)/H(+) exchange were inhibited following phospholipase D treatment compared with untreated controls. Passive efflux of Na(+) was unaffected. Treatment of sarcolemmal vesicles with phospholipase C had no effect on Na(+)/H(+) exchange. We conclude that phospholipase D-induced changes in the cardiac sarcolemmal membrane phospholipid environment alter Na(+)/H(+) exchange. | lld:pubmed |
| pubmed-article:10993782 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10993782 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10993782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993782 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10993782 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10993782 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:10993782 | pubmed:author | pubmed-author:PierceG NGN | lld:pubmed |
| pubmed-article:10993782 | pubmed:author | pubmed-author:PanagiaVV | lld:pubmed |
| pubmed-article:10993782 | pubmed:author | pubmed-author:VecchiniAA | lld:pubmed |
| pubmed-article:10993782 | pubmed:author | pubmed-author:GoelD PDP | lld:pubmed |
| pubmed-article:10993782 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10993782 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:10993782 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10993782 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10993782 | pubmed:pagination | H1179-84 | lld:pubmed |
| pubmed-article:10993782 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10993782 | pubmed:meshHeading | pubmed-meshheading:10993782... | lld:pubmed |
| pubmed-article:10993782 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10993782 | pubmed:articleTitle | Altered cardiac Na(+)/H(+) exchange in phospholipase D-treated sarcolemmal vesicles. | lld:pubmed |
| pubmed-article:10993782 | pubmed:affiliation | Division of Stroke and Vascular Disease, St. Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada R2H 2A6. | lld:pubmed |
| pubmed-article:10993782 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10993782 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10993782 | lld:pubmed |
