| pubmed-article:10991908 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C1366876 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C1833235 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C1171350 | lld:lifeskim |
| pubmed-article:10991908 | lifeskim:mentions | umls-concept:C0297666 | lld:lifeskim |
| pubmed-article:10991908 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10991908 | pubmed:dateCreated | 2000-11-15 | lld:pubmed |
| pubmed-article:10991908 | pubmed:abstractText | Tumour necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta) have been implicated in the pathogenesis of asthma. The p38 kinase inhibitor, SB 203580 inhibits TNF-alpha and IL-1beta production in vitro and in vivo. In this study the effect of SB 203580 on allergen-induced airway TNF-alpha production and inflammatory cell recruitment was investigated in sensitized Brown Norway rats. The allergen-induced increase in bronchoalveolar lavage (BAL) TNF-alpha was inhibited by SB 203580 at every dose tested (10 - 100 mg kg(-1), p.o.). In contrast, neither ovalbumin-induced eosinophilia or neutrophilia were inhibited by SB 203580 (10 - 100 mg kg(-1), p.o.). In conclusion, SB 203580 inhibits BAL TNF-alpha production by 95% without inhibiting either antigen-induced airway eosinophilia or neutrophilia. This data suggests that either the residual TNF-alpha is sufficient to drive allergen-induced inflammatory cell recruitment into the lung or that TNF-alpha is not involved in allergen-induced inflammatory cell recruitment. | lld:pubmed |
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| pubmed-article:10991908 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10991908 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10991908 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10991908 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10991908 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10991908 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:10991908 | pubmed:author | pubmed-author:BelvisiM GMG | lld:pubmed |
| pubmed-article:10991908 | pubmed:author | pubmed-author:WebberS ESE | lld:pubmed |
| pubmed-article:10991908 | pubmed:author | pubmed-author:SargentC ACA | lld:pubmed |
| pubmed-article:10991908 | pubmed:author | pubmed-author:FosterM LML | lld:pubmed |
| pubmed-article:10991908 | pubmed:author | pubmed-author:BirrellM AMA | lld:pubmed |
| pubmed-article:10991908 | pubmed:author | pubmed-author:EscottK JKJ | lld:pubmed |
| pubmed-article:10991908 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10991908 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:10991908 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10991908 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10991908 | pubmed:pagination | 173-6 | lld:pubmed |
| pubmed-article:10991908 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10991908 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10991908 | pubmed:articleTitle | Effect of the p38 kinase inhibitor, SB 203580, on allergic airway inflammation in the rat. | lld:pubmed |
| pubmed-article:10991908 | pubmed:affiliation | Department of Pharmacology, Aventis Pharmaceuticals, Rainham Road South, Dagenham, Essex, RM10 7XS. jane.escott@astrazeneca.com | lld:pubmed |
| pubmed-article:10991908 | pubmed:publicationType | Journal Article | lld:pubmed |
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