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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-11-15
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pubmed:abstractText |
Tumour necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta) have been implicated in the pathogenesis of asthma. The p38 kinase inhibitor, SB 203580 inhibits TNF-alpha and IL-1beta production in vitro and in vivo. In this study the effect of SB 203580 on allergen-induced airway TNF-alpha production and inflammatory cell recruitment was investigated in sensitized Brown Norway rats. The allergen-induced increase in bronchoalveolar lavage (BAL) TNF-alpha was inhibited by SB 203580 at every dose tested (10 - 100 mg kg(-1), p.o.). In contrast, neither ovalbumin-induced eosinophilia or neutrophilia were inhibited by SB 203580 (10 - 100 mg kg(-1), p.o.). In conclusion, SB 203580 inhibits BAL TNF-alpha production by 95% without inhibiting either antigen-induced airway eosinophilia or neutrophilia. This data suggests that either the residual TNF-alpha is sufficient to drive allergen-induced inflammatory cell recruitment into the lung or that TNF-alpha is not involved in allergen-induced inflammatory cell recruitment.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-10068590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-1374772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-7599866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-7730642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-7797792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-7997261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-8581835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-8768739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-8968371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-9295308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-9351499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-9454815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-9647257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10991908-9648711
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10991908-Administration, Oral,
pubmed-meshheading:10991908-Animals,
pubmed-meshheading:10991908-Anti-Inflammatory Agents,
pubmed-meshheading:10991908-Bronchial Hyperreactivity,
pubmed-meshheading:10991908-Bronchial Provocation Tests,
pubmed-meshheading:10991908-Bronchoalveolar Lavage,
pubmed-meshheading:10991908-Cell Movement,
pubmed-meshheading:10991908-Disease Models, Animal,
pubmed-meshheading:10991908-Enzyme Inhibitors,
pubmed-meshheading:10991908-Female,
pubmed-meshheading:10991908-Hypersensitivity,
pubmed-meshheading:10991908-Imidazoles,
pubmed-meshheading:10991908-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10991908-Ovalbumin,
pubmed-meshheading:10991908-Pyridines,
pubmed-meshheading:10991908-Rats,
pubmed-meshheading:10991908-Tumor Necrosis Factor-alpha,
pubmed-meshheading:10991908-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2000
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pubmed:articleTitle |
Effect of the p38 kinase inhibitor, SB 203580, on allergic airway inflammation in the rat.
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pubmed:affiliation |
Department of Pharmacology, Aventis Pharmaceuticals, Rainham Road South, Dagenham, Essex, RM10 7XS. jane.escott@astrazeneca.com
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pubmed:publicationType |
Journal Article
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