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pubmed-article:10987430pubmed:abstractTextA series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.lld:pubmed
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pubmed-article:10987430pubmed:articleTitleSubstituted 2-aminopyridines as inhibitors of nitric oxide synthases.lld:pubmed
pubmed-article:10987430pubmed:affiliationDepartment of Medicinal Chemistry, Merck Research Laboratories Rahway, NJ 07065, USA. william_hagmann@merck.comlld:pubmed
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