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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2001-1-4
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pubmed:abstractText |
A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:CaldwellC GCG,
pubmed-author:ChabinR MRM,
pubmed-author:ChenPP,
pubmed-author:DuretteP LPL,
pubmed-author:EsserC KCK,
pubmed-author:FletcherDD,
pubmed-author:GrantS KSK,
pubmed-author:GreenB GBG,
pubmed-author:GuthikondaRR,
pubmed-author:HagmannW KWK,
pubmed-author:HumesJ LJL,
pubmed-author:KellyT MTM,
pubmed-author:KopkaI EIE,
pubmed-author:LanzaT JTJ,
pubmed-author:LuellSS,
pubmed-author:MacCossMM,
pubmed-author:MeurerRR,
pubmed-author:MooreVV,
pubmed-author:PacholokS GSG,
pubmed-author:PaviaTT,
pubmed-author:ShahS KSK,
pubmed-author:WilliamsH RHR,
pubmed-author:WongK KKK
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pubmed:issnType |
Print
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pubmed:day |
4
|
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pubmed:volume |
10
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1975-8
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories Rahway, NJ 07065, USA. william_hagmann@merck.com
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pubmed:publicationType |
Journal Article
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