Source:http://linkedlifedata.com/resource/pubmed/id/10984554
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2000-12-1
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| pubmed:abstractText |
A large cohort of rhesus-negative women in Ireland were inadvertently infected with hepatitis C virus following exposure to contaminated anti-D immunoglobulin in 1977-8. This major iatrogenic episode was discovered in 1994. We studied 36 women who had been infected after their first pregnancy, and compared them to an age- and parity-matched control group of rhesus-positive women. The presence of hepatitis C antibody was confirmed in all 36 by enzyme-linked immunosorbent assay and by recombinant immunoblot assay, while 26 (72%) of the cohort were HCV-RNA-positive (type 1b) on PCR testing. In the 20 years post-infection, all members of the study group had at least one pregnancy, and mean parity was 3.5. They had a total of 100 pregnancies and 85 of these went to term. There were four premature births, one being a twin pregnancy, and 11 spontaneous miscarriages. One miscarriage occurred in the pregnancy following HCV infection. There were two neonatal deaths due to severe congenital abnormalities in the PCR-positive women. Of the children born to HCV-RNA positive mothers, only one (2.3%) tested positive for the virus. Significant portal fibrosis on liver biopsy was confined to HCV-RNA-positive mothers apart from one single exception in the antibody-positive HCV-RNA-negative group. Comparison with the control group showed no increase in spontaneous miscarriage rate, and no significant difference in obstetric complications; birth weights were similar for the two groups.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1460-2725
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
93
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
597-601
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10984554-Adult,
pubmed-meshheading:10984554-Case-Control Studies,
pubmed-meshheading:10984554-Congenital Abnormalities,
pubmed-meshheading:10984554-Female,
pubmed-meshheading:10984554-Fetal Death,
pubmed-meshheading:10984554-Fibrosis,
pubmed-meshheading:10984554-Hepacivirus,
pubmed-meshheading:10984554-Hepatitis C, Chronic,
pubmed-meshheading:10984554-Humans,
pubmed-meshheading:10984554-Iatrogenic Disease,
pubmed-meshheading:10984554-Infant, Newborn,
pubmed-meshheading:10984554-Infant, Premature,
pubmed-meshheading:10984554-Infectious Disease Transmission, Vertical,
pubmed-meshheading:10984554-Liver,
pubmed-meshheading:10984554-Parity,
pubmed-meshheading:10984554-Pregnancy,
pubmed-meshheading:10984554-Pregnancy Complications, Infectious,
pubmed-meshheading:10984554-RNA, Viral,
pubmed-meshheading:10984554-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10984554-Rh Isoimmunization,
pubmed-meshheading:10984554-Rho(D) Immune Globulin,
pubmed-meshheading:10984554-Twins
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Pregnancy and pregnancy outcome in hepatitis C type 1b.
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| pubmed:affiliation |
Departments of Medicine, Pathology, and Statistics, Cork University Hospital, and University College Cork, Cork, Ireland.
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| pubmed:publicationType |
Journal Article
|