Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-9-29
pubmed:abstractText
Non-small-cell carcinomas of the lung, especially adenocarcinomas, are characterized by a high degree of morphological heterogeneity. As carcinogenesis has been suggested to be a multistep process involving sequential accumulation of multiple genetic alterations, morphological heterogeneity may represent a cross-sectional view of genetic alterations within individual tumors. We therefore examined the topographical distribution of loss of heterozygosity (LOH) events within 10 non-small-cell lung cancers to investigate whether, and which, genetic alterations are accumulated in relation to morphological progression. LOH at the TP53, 17p13.3, and 3p loci was detected in six, eight, and six of 10 informative cases, respectively. In each case, all portions of the tumor shared concordant LOH despite morphological diversity. In contrast, distributions of LOH at 2q, 9p, and 22q, which have been reported to be associated with the advanced stages of tumors, were divergent in two of three, four of eight, and one of one cases with LOH, respectively. In these cases, presence of LOH was mostly related to the morphological tumor grades. These findings suggest the accumulative feature of genetic alterations in particular loci that can be seen even in individual tumors. Furthermore, the present study indicated that cross-sectional examination of individual tumors is also important for better understanding of molecular pathogenesis of lung cancers.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-10218505, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-10547393, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-1314694, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-1347916, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-2188735, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-2362938, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-2403196, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-2554494, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-3338044, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-3946300, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-7563168, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-7585215, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-7837389, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-7910096, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-7923210, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-7992847, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-8311114, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-8380124, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-8603409, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-8636763, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-8913723, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-8980398, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9187106, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9196251, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9197523, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9308707, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9491321, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9559342, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9788625, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9798680, http://linkedlifedata.com/resource/pubmed/commentcorrection/10980137-9859753
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
985-93
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Topographical distributions of allelic loss in individual non-small-cell lung cancers.
pubmed:affiliation
Department of Pathology and Clinical Laboratorie, Aichi Cancer Center Hospital, Nagoya, Japan. yyatabe@aichi-cc.pref.aichi.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't