Source:http://linkedlifedata.com/resource/pubmed/id/10976535
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-12-6
|
| pubmed:abstractText |
The aim of this study was to investigate the mechanisms responsible for the emergence in some HIV-1-infected individuals of highly aggressive, syncytia-inducing (SI) HIV-1 strains, which have been shown to use CXCR4 as co-receptor to enter target cells. To this end, the percentages of circulating CXCR4+CD4+ T cells were evaluated by flow cytometry in 39 untreated and 61 highly active antiretroviral therapy (HAART)-treated HIV-1-infected individuals in comparison with 35 HIV-1 seronegative subjects. Plasma viremia was also measured, and HIV primary isolates, from both untreated and HAART-treated HIV-1-infected subjects, were tested for the presence of SI strains. The results of this study showed enhanced proportions of CXCR4+CD4+ T cells in untreated patients in comparison with HAART-treated and healthy subjects. Furthermore, the results of a 12-month longitudinal study in a cohort of 11 patients undergoing HAART showed a significant reduction of CXCR4 expression after successful therapy. Finally, a significant positive correlation among the proportions of circulating CXCR4-expressing CD4+ T cells, plasma viremia, and the probability to isolate SI strains was found. These in vivo data are in keeping with previous in vitro results suggesting a bidirectional link between HIV-1 and CXCR4 expression on CD4+ T cells, and provide some clues to understanding the mechanisms exerting a selective pressure toward the emergence of SI strains.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1368-4736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
19-24
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10976535-Adult,
pubmed-meshheading:10976535-Aged,
pubmed-meshheading:10976535-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:10976535-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10976535-Cells, Cultured,
pubmed-meshheading:10976535-Female,
pubmed-meshheading:10976535-Flow Cytometry,
pubmed-meshheading:10976535-Giant Cells,
pubmed-meshheading:10976535-HIV Infections,
pubmed-meshheading:10976535-HIV Seronegativity,
pubmed-meshheading:10976535-HIV-1,
pubmed-meshheading:10976535-Humans,
pubmed-meshheading:10976535-Kinetics,
pubmed-meshheading:10976535-Longitudinal Studies,
pubmed-meshheading:10976535-Male,
pubmed-meshheading:10976535-Middle Aged,
pubmed-meshheading:10976535-Receptors, CXCR4,
pubmed-meshheading:10976535-Viral Load,
pubmed-meshheading:10976535-Viremia
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Enhanced expression of the CXCR4 co-receptor in HIV-1-infected individuals correlates with the emergence of syncytia-inducing strains.
|
| pubmed:affiliation |
Department of Internal Medicine, University of Florence, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|