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pubmed:abstractText |
IgA nephropathy is the most common glomerular disease. Mechanisms leading to its occurrence and controlling the evolution of the disease remain largely unknown. Various genetic factors have been found, mostly implicating immunologically relevant genes (IgH, TCR, human lymphocyte antigen, and complement loci). A regulatory region recently identified downstream, the alpha1 gene of the IgH locus, was a likely candidate for the control of IgA1 production in patients. Alleles of this region, differing by size, sequence, and orientation of the alpha1 hs1,2 transcriptional enhancer, were first identified through Southern blot hybridization.
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pubmed:affiliation |
Laboratoire d'Immunologie, CNRS EP 118 Faculté de Médecine and Institut Universitaire de France, and Service de Néphrologie, C.H.U. Dupuytren, Limoges; and Service de Néphrologie, C.H.U. Jean Bernard, Poitiers, France.
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